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Extractive of over-ground part of bulbus fritillariae cirrhosae as well as extracting and purifying method and application of extractive

An aerial part and purification method technology, applied in the field of the above-ground part of Fritillaria fritillary, can solve problems such as waste of medicinal materials of Fritillaria, and achieve the effects of promoting ecological environment protection and sustainable utilization of resources, stable method and easy operation.

Inactive Publication Date: 2013-05-22
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to long-term medication habits, the above-ground parts of Fritillaria sichuanensis are basically discarded, resulting in a waste of medicinal resources of Fritillaria chinensis

Method used

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  • Extractive of over-ground part of bulbus fritillariae cirrhosae as well as extracting and purifying method and application of extractive
  • Extractive of over-ground part of bulbus fritillariae cirrhosae as well as extracting and purifying method and application of extractive
  • Extractive of over-ground part of bulbus fritillariae cirrhosae as well as extracting and purifying method and application of extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Preparation method of the aerial part extract of Wabu Fritillaria of the present invention

[0029] Use the aboveground part of Fritillaria wabu, add 25 times the amount of ethanol solution with a concentration of 75% to soak the medicinal material for 1.5 hours, then extract twice, 1.0 hours each time, filter, combine the filtrates, and recover the solvent under reduced pressure to obtain a concentrated solution. Add 1mol / L NaOH solution to the concentrated solution to adjust the pH value to 8.5, absorb with X-5 macroporous resin, and then elute with 50 times the amount of acidic ethanol solution with a concentration of 75% and a pH value of 3. After determination, the total alkaloid content in the extract is 18%.

Embodiment 2

[0030] Example 2 Screening of the preparation method of the aerial part extract of Wabu Fritillaria of the present invention

[0031] 1 Instruments and materials

[0032] 1.1 Instrument

[0033] Ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.), UV1100 ultraviolet spectrophotometer (Shanghai Tianmei Scientific Instrument Co., Ltd.), high performance liquid chromatography 1200 (Agilent, USA), UPT-I-10T UPT series ultra- Water purifier (Chengdu Ultra Pure Technology Co., Ltd.), BS124S electronic balance (Sartorius Scientific Instrument Co., Ltd.), rotary evaporator R-201 constant temperature water bath W201B (Shanghai Shensheng Biotechnology Co., Ltd.), circulating water multi-purpose Vacuum pump SHB-III (Zhengzhou Great Wall Technology Industry and Trade Co., Ltd.), portable acidity meter pHB-1 type (Hangzhou Aoli Lilong Instrument Co., Ltd.)

[0034] 1.2 Materials

[0035] Aerial parts of Fritillaria (provided by Chengdu New Lotus Decoction Pieces Co., Ltd.), Fri...

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Abstract

The invention provides an extractive of an over-ground part of bulbus fritillariae cirrhosae as well as an extracting and purifying method and an application of the extractive. According to the experiment, the pharmacological experiments approves that the stem leaf extractive of the over-ground part of the bulbus fritillariae cirrhosae has identical and even better effects on relieving a cough, eliminating phlegm and relieving asthma compared with the underground bulb parts, which provides a theoretical basis for developing the non-medicinal parts of the Fritillaria unibracteata and increasing the medical range of the bulbus fritillariae cirrhosae, provides possibility for enlarging the medical source of the bulbus fritillariae cirrhosae, reduces the waste of the bulbus fritillariae cirrhosae plant source, brings enormous economic and social benefits, and greatly promotes the protection of an ecological environment and the sustainable utilization of resources. The preparation method of the extractive of the over-ground part of the bulbus fritillariae cirrhosae can be used for effectively enriching alkaloids compounds of the bulbus fritillariae cirrhosae, is simple and convenient to operate, is stable, and has good industrial application prospect.

Description

technical field [0001] The invention relates to the extract of the aboveground part of Fritillaria sichuanensis, its extraction and purification method and application. Background technique [0002] Fritillaria, FritillariacirrhosaD of Liliaceae. Don, Fritillaria unibracteataHsiaoetK.C.Hsia, Fritillaria przewalskii Maxim., Fritillaria taipaiensis P.Y.Li, Fritillaria unibracteata Hsiao et K.C.Hsia var.wabuensisang(Set.Y. The dried bulbs of S.C.Yue) Z.D.Liu, S.Wang et S.C.Chen have the effects of relieving cough and reducing phlegm, clearing away heat and dissipating stagnation. [0003] At present, the medicinal part of Chuan Fritillaria is commonly used as the bulb, and its effective part is the alkaloid component of isosteroids. Due to long-term medication habits, the above-ground parts of Fritillaria sichuanensis are basically discarded, resulting in a waste of medicinal resources of Fritillaria chinensis. With the rapid expansion of the cultivated area of ​​Fritillaria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/10A61P11/14
Inventor 董小萍任波赵高琼谭玉柱谢运飞童婷婷
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE