Preparation method of high-definition endoscope mucus-removal defoaming composite preparation

Abstract

The invention discloses a preparation method of a high-definition endoscope mucus-removal defoaming composite preparation, which comprises the following steps: simultaneously pouring chymotrypsin, sodium bicarbonate powder and dimethyl silicon oil powder into a graduated cuvette, adding warm boiled water, and completely dissolving by stirring. The invention solves the problem that defoaming and mucus protein removal can not be completed at the same time in gastrointestinal tract detection process of the existing high-resolution endoscope, increases the detection rate of minimal diseases, and enhances the inspection visual field definition and inspection efficiency of the endoscope. The clinical practice proves that the high-definition endoscope mucus-removal defoaming composite preparation can satisfy the requirements, can effectively avoid missed diagnosis, facilitates the early treatment of patients, reduces the subsequent treatment cost for the patients, and has favorable economic benefit.

Description

technical field [0001] 本发明涉及一种高清内镜去粘液消泡复合制剂的制备方法,主要用于高清内镜检查及内镜治疗中祛除胃十二指肠中的粘液和泡沫。 Background technique [0002] 医疗上使用高清内镜来检测胃肠道肿瘤和明确肿瘤浸润深度是一种有用方法,然而胃肠道内粘液和泡沫常常影响内镜的视野,导致微小病灶检出率下降和检查时间延长。二甲基硅油是一种降低气泡表面张力的祛泡剂,能够使胃肠泡沫融合,从而提高内镜检查的清晰度、提高诊断率及提高内镜检查的满意度,但其却无法消除胃肠道中的粘液蛋白。糜蛋白酶具有肽链内切酶的作用,可将蛋白质大分子的肽链切断,并可将某些脂类水解,通过上述机制能够有效分解胃壁附着的粘液蛋白。但因其无降低泡沫表面张力的作用,无法消除胃肠道泡沫及气泡,单独运用无法满足临床需要。为此寻找一种既能够消除泡沫又能够祛除粘液蛋白的药物成为临床工作中的迫切需要。 Contents of the invention [0003] 本发明要解决的技术问题是:为了解决上述背景技术中现有的高清内镜在检测胃肠道时存在的困难,提供一种高清内镜去粘液消泡复合制剂,既能够消除泡沫又能够祛除粘液蛋白。 [0004] 本发明所采用的技术方案为:一种高清内镜去粘液消泡复合制剂的制备方 法:将糜蛋白酶、碳酸氢钠粉、二甲基硅油粉同时倒入带刻度的小杯,加温开水,搅拌使完全溶解即可。 [0005] 进一步地,本发明所述复合制剂的重量百分比原料制备为:糜蛋白酶:0.01-0.02%、碳酸氢钠粉:0.1-0.2%、二甲基硅油粉:1.23-2.46%、纯水:97-99%。 [0006] 进一步地,本发明所述的糜蛋白酶具有肽链内切酶及脂酶作用:可将蛋白质大分子的肽链切断,成为分子量较小的肽,或在蛋白分子肽链端上作用,使氨基酸分出;并可将某些脂类水解。通过此作用分解胃壁附着的粘液;二甲基硅油为抗泡沫剂,二甲硅油表面张力小,能改变气泡表面张力,使其破裂,从而能使胃肠道内泡沫中贮留的气体得以排出,可提高胃镜检查的清晰度,更清晰地显示胃肠道黏膜表面的细微结构。 [0007] 本发明的有益效果是:本发明解决了现有的高清内镜在检测胃肠道时存在的不能够同时消除泡沫和祛除粘液蛋白的问题,提高了微小病灶的检出率,同时提高内...

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is: in order to solve the difficulties existing in the detection of the gastrointestinal tract by the existing high-definition endoscope in the above-mentioned background technology, a high-definition endoscope anti-mucus defoaming compound preparation is provided, which can not only eliminate foam but also Remove mucus