Pharmaceutical composition of piribedil/folic acid compound and purpose thereof

A technology of piribedil and composition, which is applied in the field of pharmaceutical compositions of piribedil/folate compounds, and achieves the effects of preventing and reducing stroke, taking medicine conveniently, and overcoming low drug efficacy.

Inactive Publication Date: 2013-06-05
SUZHOU FAMO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Entocapone is 100-200 mg each time, and the frequency of taking the compound levodopa is the same as that of the compound levodopa. Levodopa taken together, single use is invalid

Method used

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  • Pharmaceutical composition of piribedil/folic acid compound and purpose thereof
  • Pharmaceutical composition of piribedil/folic acid compound and purpose thereof
  • Pharmaceutical composition of piribedil/folic acid compound and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1. Preparation of tablet

[0034] prescription:

[0035]

[0036] Preparation Process:

[0037] (1) Take the prescription amount of piribedil and folic acid and pass through a 100-mesh sieve and mix them uniformly by the method of increasing in equal amounts for subsequent use;

[0038] (2) Other auxiliary materials are passed through a 100-mesh sieve and dried at 75°C for 2 hours;

[0039] (3) Mix the starch, microcrystalline cellulose, and CMS.Na according to the prescription amount, and then mix them evenly with the mixed raw material drug in equal increments;

[0040] (4) Add an appropriate amount of binder to prepare soft materials, granulate with a 24-mesh sieve, granulate with a 20-mesh sieve, and dry at 40-75°C.

[0041] (5) Add an appropriate amount of magnesium stearate to the dry granules and mix evenly. After the content is determined, compress into tablets and pack.

[0042] 3 times a day, 1 tablet each time.

Embodiment 2

[0043] Embodiment 2. The preparation of capsule

[0044] prescription:

[0045]

[0046]

[0047] Preparation Process:

[0048] According to the prescription ratio, take lactose, microcrystalline cellulose, starch, and carboxymethyl starch sodium and dry them at about 100°C for about 2 hours, pass through a 100-mesh sieve; pass the raw material through a 100-mesh sieve, and increase the amount of the above-mentioned excipients in equal increments Mix well and fill the capsules.

[0049] 3 times a day, 1 capsule each time.

Embodiment 3

[0050] Example 3. Preparation of Sustained Release Tablets

[0051] prescription:

[0052]

[0053] Preparation Process:

[0054] According to the proportion of the prescription, the raw material is mixed with hypromellose, citric acid is dissolved in ethanol as a wetting agent to make a soft material, granulated, dried, sized, mixed with magnesium stearate, pressed Slice and serve.

[0055] 3 to 5 times a day, 3 to 5 tablets each time.

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PUM

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Abstract

The invention relates to pharmaceutical composition of piribedil / folic acid compound and purpose thereof and belongs to the technical field of pharmacy. The pharmaceutical composition contains medical dose piribedil, medical dose folic acid compound and pharmaceutical acceptable carriers, wherein the dose of the piribedil is 25-100mg, and the dose of the folic acid compound is 0.2-1.6mg. The pharmaceutical composition has the advantages that by means of synergistic effects of multiple target points, curative effects on anti-Parkinson disease are enhanced, and life quality of patients is improved; stroke risk of Parkinson patients can be effectively prevented and reduced through homocysteine (Hcy) target points; and in addition, patients can take medicine conveniently.

Description

technical field [0001] The invention relates to a pharmaceutical composition of piribedil / folate compound and its application, belonging to the technical field of pharmacy. Background technique [0002] Parkinson's disease (PD) is a chronic progressive disease of extrapyramidal dysfunction in the central nervous system. The main pathological manifestations of PD are the degeneration of dopamine (DA) neurons in the substantia nigra, and the decrease of the content of central neurotransmitter DA, and the degree of depletion of DA is consistent with the severity of PD; at the same time, it can also be accompanied by acetylcholine (Ach), 5- Abnormality and imbalance of various neurotransmitters such as serotonin (5-HT), norepinephrine (NE), γ-aminobutyric acid, and neuropeptides, resulting in a series of clinical symptoms, such as muscle tremors, stiffness, and postural disturbances , movement difficulties, etc. According to reports, there are about 1.5 million PD patients in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/506A61P25/16
Inventor 王玉姝
Owner SUZHOU FAMO BIOLOGICAL TECH
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