Sophocarpidine, oxymatrine glycyrrhetinic acid double salt, and preparation method and use thereof

A technology of ginseng, licorice, oxybitter, applied in the directions of organic chemistry, pharmaceutical formulations, steroids, etc., can solve the problems of small number of rabbits, no drinking water control, etc., and achieves reduced dosage, good synergy, and high yield. Effect

Inactive Publication Date: 2013-06-05
TIANJIN HEERBO BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the number of rabbits used in the experiment was small, and the situation of d...

Method used

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  • Sophocarpidine, oxymatrine glycyrrhetinic acid double salt, and preparation method and use thereof
  • Sophocarpidine, oxymatrine glycyrrhetinic acid double salt, and preparation method and use thereof
  • Sophocarpidine, oxymatrine glycyrrhetinic acid double salt, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of double salt of matrine and glycyrrhetinic acid

[0038] Mix 24.8g of matrine and 47g of glycyrrhetinic acid (molar ratio 1:1), add 1000ml of methanol, heat to 35°C, stir vigorously until dissolved, leave it overnight, crystallize, filter to obtain 65.3g of white crystals, yield 90.9%.

[0039]The obtained product was recrystallized in methanol, and its melting point was determined to be 270-280°C. By elemental analysis: C75.28 (75.17), H9.79 (9.81), N3.87 (3.90), O11.12 (11.13). The H NMR spectrum is as figure 1 shown.

Embodiment 2

[0041] Preparation of double salt of matrine and glycyrrhetinic acid

[0042] Mix 24.8g of matrine and 47g of glycyrrhetinic acid (molar ratio 1:1), add 800ml of acetone, heat to 50°C, stir until dissolved, let cool, crystallize, and filter with suction to obtain 69.1g of white crystals, yield 96.2%. Recrystallized in methanol to obtain pure product.

Embodiment 3

[0044] Preparation of double salt of matrine and glycyrrhetinic acid

[0045] Mix 49.6g of matrine and 47g of glycyrrhetinic acid (molar ratio 2:1), add 1200ml of ethanol, heat at 35°C until dissolved, let cool, crystallize, and filter to obtain 70.2g of white powder with a yield of 97.8%. Recrystallized in methanol to obtain pure product.

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Abstract

The invention relates to a compound of sophocarpidine and glycyrrhetinic acid double salt, a compound of oxymatrine glycyrrhetinic acid double salt, and a composition, a preparation method and use thereof, and particularly relates to the use of two double salts in the treatment of inflammation, bacterial infected skin diseases and allergic dermatitis. The polarity of the glycyrrhetinic acid, easy oxidation of sophocarpidine, and strong moisture adsorption of oxymatrine are well improved by the sophocarpidine glycyrrhetinic acid double salt; the preparation method is simple and easy to operate, and is high in yield; meanwhile, a good synergistic effect is displayed in anti-inflammation and antibiosis; and the dosage is obviously reduced.

Description

technical field [0001] The invention relates to a pharmaceutical compound for treating inflammation and bacterial infection diseases, and also includes a method for preparing the compound, a pharmaceutical composition containing the compound, and the therapeutic use of the compound. Background technique [0002] Licorice (Glycyrrhize glabra L.) is a common medicinal and edible food. As a natural sweetener, licorice extract is widely used in candy and canned food. The sweetness of licorice comes from Glycyrrhizic acid and Glycyrrhetinic acid. acid). The former is a class of triterpenoid saponins, accounting for about 4% to 5% of the dry weight of licorice root. [0003] Pharmacological Actions of Glycyrrhetinic Acid [0004] 1. Anti-inflammatory and anti-immune effects: Glycyrrhetinic acid has anti-inflammatory effects like phenylbutazone or hydrocortisone. Its anti-inflammatory and anti-allergic reactions may be related to inhibition of capillary permeability, anti-histam...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07D471/22A61K31/56A61K31/4375A61P29/00A61P31/04A61P17/00A61P37/08
Inventor 陈虹高颖曹波伍家泉
Owner TIANJIN HEERBO BIOLOGICAL TECH CO LTD
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