Chinese adenocarcinoma of lung cell strain without transferring potential

Abstract

The invention relates to a Chinese adenocarcinoma of lung cell strain Yang6 without transferring potential and an application and belongs to the biological zooblast system field. The Chinese adenocarcinoma of lung cell strain without transferring potential adopts pleural effusion of initial diagnosis later period adenocarcinoma of lung patients as cell primary culture, so that the Chinese adenocarcinoma of lung cell strain Yang6 without transferring potential is acquired, wherein a preservation number is CGMCC number (No.) 5404. The Chinese adenocarcinoma of lung cell strain Yang6 without transferring potential adherently grows on walls, possesses non-transitivity, and can be used as a people adenocarcinoma of lung comparative study cell model, wherein the shapes of cells are attractive and in a circle shape or a partial polygon shape, so that growth speed is low. The Chinese adenocarcinoma of lung cell strain without transferring potential has unique molecular biology character, heterogeneity, and polymorphism, and has a wide prospect in the application of disclosing a transferring mechanism of people adenocarcinoma of lung and selection of anti-metastasis drugs.

Description

technical field [0001] The invention belongs to the field of microbial animal cell lines, relates to a Chinese lung adenocarcinoma cell line, in particular to a Chinese human lung adenocarcinoma cell line (The Chinese Human Lung Adenocarcinoma cell, Yang6, especially the parental cell tumorigenic but not metastatic) A Chinese lung adenocarcinoma cell line (Yang6) with no metastatic properties and its use. Background technique [0002] Lung cancer is one of the malignant diseases that seriously threaten the survival and development of human beings, and has become the number one killer of tumor diseases. According to statistics, about 174,470 new cases of lung cancer were diagnosed in the United States in 2006, accounting for about 13% (male) and 12% (female) of all tumors, and the incidence rate is second only to skin cancer; about 162,460 people died of lung cancer, accounting for about 31% (male) and 26% (female) of all tumors, ranking first in mortality [1～2] ; There are...

AI Technical Summary

Problems solved by technology

[0003] At present, in clinical treatment, the main reason for the long-term high mortality rate of lung cancer is the difficulty of early diagnosis and its high metastases. Many patients are found to have multiple organ metastases at the first diagnosis; because the biological mechanism of lung cancer metastasis is still unclear, There is a lack of effective treatment methods in clinical practice. Therefore, studying the pathogenesis of lung cancer metastasis and exploring effective diagnosis and treatment methods are the long-term efforts of scholars at home and abroad.

At present, with the development of basic disciplines such as molecular biology, signal transduction pathways, and protein function research, the research methods of human disease pathogenesis have developed by leaps and bounds. However, due to various objective limitations, research in this field has not yet achieved important breakthroughs.

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