Novel application for angelica polymorpha maxim and extract thereof

A technology of extract and Zijinsha, which is applied in the direction of medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve the problems that Zijinsha and its extracts have not yet been discovered

Active Publication Date: 2013-06-19
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, no patent applications and literature reports on the application of Zijinsha and its extracts in myocardial ischemia and myocardial ischemia-reperfusion have been found.

Method used

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  • Novel application for angelica polymorpha maxim and extract thereof
  • Novel application for angelica polymorpha maxim and extract thereof
  • Novel application for angelica polymorpha maxim and extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Zijinsha Extract 1

[0027] After taking 500g of Zijinsha medical material and pulverizing it, heat and reflux extraction with 80% ethanol for 2 times, each extraction for 2 hours, the amount of solvent used is 4000ml, the combined extracts are concentrated to dryness under reduced pressure to obtain 96g of ethanol extract. A proper amount of the ethanol extract is weighed, and the total content of the total coumarins and chromones measured by UV-Vis spectrophotometry is 29.4%. Determination of Hydrated Oxidized Precurolactone, Eperprenol, 3'(R)-+-Hyculol, 3'-O-Acetyl Halgol, and Isoimperatorin by High Performance Liquid Chromatography They are 8.24%, 0.68%, 0.41%, 0.43%, and 1.89%, respectively.

Embodiment 2

[0028] Example 2 Preparation of Zijinsha Extract 2

[0029] After crushing 50 g of Zijinsha medicinal material, ultrasonically extract with methanol for 0.5 hours each time, the amount of solvent used is 400 ml, the combined extracts are concentrated to dryness under reduced pressure to obtain 4.2 g of methanol extract. A proper amount of methanol extract was weighed, and the sum of the contents of coumarins and chromones was measured by ultraviolet-visible spectrophotometry to be 26.3%. Determination of Hydrated Oxidized Precurolactone, Eperprenol, 3'(R)-+-Hyculol, 3'-O-Acetyl Halgol, and Isoimperatorin by High Performance Liquid Chromatography They are 7.37%, 0.63%, 0.31%, 0.33%, and 1.61%, respectively.

Embodiment 3

[0030] Example 3 Preparation of Zijinsha Extract 3

[0031] After taking 100g of Zijinsha medicinal material and pulverizing it, extract by cold soaking in acetone twice for 24 hours each time, the amount of solvent used is 1000ml, the combined extracts are concentrated to dryness under reduced pressure to obtain 9.2g of acetone extract. An appropriate amount of acetone extract was weighed, and the sum of the contents of coumarins and chromones was measured by ultraviolet-visible spectrophotometry to be 33.5%. Determination of Hydrated Oxidized Precurolactone, Eperprenol, 3'(R)-+-Hyculol, 3'-O-Acetyl Halgol, and Isoimperatorin by High Performance Liquid Chromatography They were 9.73%, 1.04%, 0.86%, 0.88%, and 2.31%, respectively.

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Abstract

The invention discloses a novel application for angelica polymorpha maxim and the extract thereof. The inventor proves via experiments that angelica polymorpha maxim extracts with different dosages can be used for effectively preventing or relieving the myocardial damages caused by myocardial ischemia reperfusion after being orally administrated in advanced.

Description

technical field [0001] The present invention relates to the use of a plant extract, in particular to a new use of Zijinsha and its extract in the preparation of treating or alleviating myocardial ischemia mainly caused by myocardial ischemia-reperfusion injury. Background technique [0002] Zijinsha comes from the root of Angelica polymorpha Maxim, a plant belonging to the Umbelliferae family. It has the functions of warming the middle and dispelling cold, regulating qi and relieving pain. It mainly contains coumarin, chromone, volatile oil and other ingredients. Previous experiments have confirmed that purple gold sand has good effects of inhibiting gastrointestinal smooth muscle spasm, analgesia, anti-ulcer, and protecting gastric mucosa. [0003] Ischemic cardiomyopathy represented by myocardial infarction and coronary artery stenosis is one of the leading causes of death today. According to the report of the World Health Organization, acute coronary occlusion will becom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61P9/10
Inventor 王永安于能江杨郁李万华骆媛关雷刘艳芹
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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