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Method for controlling quality of liquorice and liquorice preparation

A quality control method and technology of licorice, applied in measuring devices, instruments, scientific instruments, etc., to achieve the effects of good linear relationship, good reproducibility, and high sample recovery rate

Inactive Publication Date: 2013-06-26
惠州市九惠制药股份有限公司
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  • Application Information

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Problems solved by technology

However, these methods only carry out quality control on one or two components in licorice, and cannot reflect the complete quality of licorice medicinal materials and Chinese patent medicine preparations containing licorice, and are very expensive to instruments. Poor specificity, cumbersome operation, poor controllability, poor stability of content determination results, etc., affect the generalizability of the standard

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  • Method for controlling quality of liquorice and liquorice preparation
  • Method for controlling quality of liquorice and liquorice preparation
  • Method for controlling quality of liquorice and liquorice preparation

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Embodiment

[0032] Determination of liquiritin, isoliquiritin, glycyrrhizin, isoliquiritigenin, glycyrrhizic acid, licorice The content of the six main active ingredients of hypoxic acid.

[0033] The instruments used are: high performance liquid chromatography (Agilent 1100 series: Agilent G1311A pump, Agilent G1316A ultraviolet detector, Agilent G1313A autosampler); SL4001N electronic balance (Shanghai Minqiao Precision Technology Instrument Co., Ltd.); ultrasonic oscillation device (power 300W, frequency 40kHz).

[0034] (1) HPLC analysis Chromatographic conditions Chromatographic column: Agilent HC-C 18 Column (4.6mm×250mm, 5μm); mobile phase: acetonitrile: 0.04% formic acid solution; gradient elution method: 0min→4min→20min→25min→38min→50min→60min, acetonitrile 20%→20%→38%→ 55%→90%→90%→20%; flow rate: 1ml min -1 ;Column temperature: 30°C; Detection wavelength: 250nm, 365nm, the number of theoretical plates should not be less than 2000 based on glycyrrhizic acid.

[0035] (2) Pre...

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Abstract

The invention relates to a method for controlling quality of a liquorice medicinal material and a liquorice preparation. The method concretely relates to the step of simultaneously determining the content of the liquorice medicinal material and the content of six main active ingredients, namely liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid and glycyrrhetinic acid in the liquorice preparation by utilizing a high performance liquid chromatography. A new method for controlling the quality of the liquorice and the liquorice preparation is established and the six main active ingredients, namely liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizic acid and glycyrrhetinic acid are quantitatively determined simultaneously by utilizing the high performance liquid chromatography. Confirmed by methodological investigation and test, the method is simple and convenient, correct in result and good in reproducibility, the defect of the existing quality control is overcome, and the quality control on the liquorice and the liquorice preparation is perfect and scientific.

Description

Technical field: [0001] The present invention involves the quality control method of licorice medicinal materials and their preparations, and it is specific to: high -efficiency liquid chromatography method at the same time determine the licorice, vascin, licorice, licorice, licoroic acid, licorice secondary acid in the medicinal material and their preparationsThe content of six main active ingredients. Background technique: [0002] Licorice is the dry roots and rhizomes of Glycyrrhiza Inflata Bat or Glycyrrhiza Glabra L in Glycyrrhiza Uralensis Fisch, Glycyrrhiza UralesAs early as two thousand years ago, "Shennong Materia Medica" was listed as a medicine for medicine.Chinese medicine in my country believes that licorice nourish the spleen and nourish qi, cough and lungs, relieve detoxification, and reconcile 100 medicines. Therefore, there is the saying of "ten squares and nine grass", and enjoy the reputation of "the king of Chinese herbal medicine". [0003] The chemical com...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 黄辉球刘强江洁
Owner 惠州市九惠制药股份有限公司
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