Method for preparing water-soluble fluorescent silicon nanoparticle by utilizing microwave radiation

Abstract

The invention discloses a method for preparing a water-soluble fluorescent silicon nanoparticle by utilizing microwave radiation. The method comprises the steps of: mixing silicon source with trisodium citrate, disodium citrate, citric acid, glutaric acid or butanedioic acid to obtain a precursor solution, putting the precursor solution into a special glass tube for the microwave radiation, and carrying out the microwave radiation in a microwave reactor, so as to prepare the water-soluble fluorescent silicon nanoparticle. The method disclosed by the invention is completely carried out in an aqueous phase and has the advantages that the operation is safe, fast, simple and convenient, the toxin is low, and the raw material is safe and easily available; and the obtained water-soluble fluorescent silicon nanoparticle has excellent monodispersity and fluorescent property, high quantum yield and good stability and water solubility and can be taken as a fluorescent maker to be widely applied to biological detection and analysis.

Description

technical field [0001] The invention belongs to the technical field of functional nanometer materials, and relates to a preparation process of water-soluble fluorescent silicon nanoparticles, in particular to a method for preparing water-soluble fluorescent silicon nanoparticles by microwave radiation. Background technique [0002] Due to its unique optical / electrical / mechanical properties, surface modification and good biocompatibility, functional silicon nanomaterials have increasingly attracted widespread attention from scientists (Nature2000, 408, 440-444; Science2002, 296, 1293-1297; Science2003, 299, 1874-1877; Science 2006, 313, 1100-1104.). Of particular concern is that fluorescent silicon nanoparticles, a representative zero-dimensional silicon nanomaterial, are expected to be widely used in biology and medicine because of their good biocompatibility and low toxicity (Science2005, 307, 538-544; Chem. Roc. Rev. 2010, 39, 4234-4243; Nano Today 2010, 5, 282-295.). Ho...

AI Technical Summary

Problems solved by technology

However, although these methods can greatly enhance the water dispersibility of silicon nanoparticles, the process is relatively complicated (for example, it is first necessary to prepare hydrophobic silicon nanoparticles and then modify them with hydrophilic groups). , and the modification process is easy to damage the surface of silicon nanoparticles, affecting its physical / chemical properties (acrylic acid / allylamine modified silicon nanoparticles have poor pH stability; polymer / microbeam modified silicon nanoparticles are too large in size (60- 300nm)) (Angew. Chem. Int. Ed. 2009, 121, 134-138; Nano Today 2010, 5, 282-295; ACS Nano 2011, 5, 413-423)

In recent years, although there are also reports on water-soluble silicon nanoparticles, most of them are from large to small (that is, top-down, using large silicon nanoparticles, silicon oxide powder, and silicon nanowires as silicon sources). Preparation method, the prepared silicon nanoparticles are difficult to control the size, and the fluorescence quantum efficiency is relatively low (J.Am.Chem.Soc.2011,133,14192-14195; Angew.Chem.Int.Ed.2012,51,8485 -8489.)

This largely limits the development of silicon nanoparticle-based biological applications

Images