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Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition

A composition and drug technology, applied in respiratory diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as lack of non-specific antidiarrheal treatment

Inactive Publication Date: 2013-07-10
奥列格·伊里奇·爱泼斯坦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Morphine is effectively administered by injection, but there appears to be a lack of pharmaceutically acceptable material means for the oral administration of morphine as an analgesic, anesthesia aid, antitussive and in the field of pharmacy and medicine. nonspecific antidiarrheal therapy

Method used

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  • Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition
  • Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition
  • Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Thirty male guinea pigs weighing 350-400 g were used for the experiments. Cough was induced by inhaling 30 μM capsaicin for 5 min using a nebulizer. The number of coughing episodes is counted within 15 minutes. Cough was induced twice: one before drug administration (baseline) and the second after drug administration. Distilled water (120 μL / guinea pig) was administered to the control group. A very low dose of anti-morphine antibody (40 μL / guinea pig) was administered to the second group. The complex (120 μL / guinea pig) was given a very low dose of anti-bradykinin antibody (ULDB), a very low dose of anti-histamine antibody (ULDH) and a very low dose of anti-morphine antibody (ULDM) to the third group. Three doses were administered orally (oral drops) at 120-minute intervals, the last 15 minutes before capsaicin-induced cough.

[0098] The study showed that the compound drug ULDB+ULDH+ULDM showed more significant antitussive effect than ULDM alone. The drugs suppres...

Embodiment 2

[0104] Tablets weighing 300 mg were used, which were saturated (6 mg / tablet) with a pharmaceutical composition containing an aqueous-alcoholic solution of an affinity-purified, potentiated form of the polyclonal rabbit antibody as follows: Bradykinin antibody (ULDB), very low dose antihistamine antibody (ULDH) and very low dose antimorphine antibody (ULDM); 12 、100 30 、100 50 Obtained as a result of extremely high dissolution times, corresponding to a mixture of C12, C30 and C50 homeopathic dilutions.

[0105]Evaluate the efficacy and safety of the compound compound ULDB+ULDH+ULDM based on the results of an open-label observational clinical study involving 107 subjects aged 19-82 years (average age 47.60±1.56 years) , who was being treated as an outpatient due to viral upper respiratory infection (URI) (acute pharyngitis / nasopharyngitis, acute laryngitis / laryngotracheitis) and / or lower respiratory infection (acute bronchitis). In addition to fever, intoxication, and catarrh...

Embodiment 3

[0120] Tablets weighing 300mg are used. The tablets were treated with an affinity-purified very low dose solution of anti-bradykinin polyclonal rabbit antibody (ULDB), anti-histamine polyclonal rabbit antibody (ULDH) and anti-morphine polyclonal rabbit antibody (ULDM). Dipping (6mg / tablet), each antibody as the matrix solution in 100 12 、100 30 、100 50 Obtained as a result of a high dilution, equivalent to a mixture of C12, C30 and C50 homeopathic dilutions.

[0121] Based on the upcoming multi-center open-label comparative clinical study, the efficacy and safety of the compound compound ULDB+ULDH+ULDM will be evaluated. Currently, data are available for 20 patients who have completed treatment. Fourteen patients received the compound compound ULDB+ULDH+ULDM at the dose of 2 tablets 3 times a day for the first three days and 1 tablet 3 times a day for the next 4 days. 6 patients received 1 tablet 3 times a day (codeine + sodium bicarbonate + licorice + herb Cassia lance...

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Abstract

The present invention is concerned with a combination pharmaceutical composition comprising a) an activated-potentiated form of an antibody to bradykinin, b) an activated-potentiated form of an antibody to histamine and c) an activated-potentiated form of an antibody to morphine and method for treating and preventing upper respiratory tract conditions or disorders and the symptoms associated therewith by administration of the combination composition.

Description

technical field [0001] A compound pharmaceutical composition comprising (a) an anti-bradykinin antibody in an active enhanced form, (b) an anti-histamine antibody in an active enhanced form, and (c) an anti-morphine antibody in an active enhanced form and methods of treating acute and chronic respiratory disorders or conditions and cough symptoms. Background technique [0002] Human respiratory infections and coughs have caused widespread suffering for centuries. These infections are generally believed to be caused by microorganisms, such as bacteria and viruses, which may be airborne or contagious by direct contact. The early stages of infection are often characterized by sinus congestion, often with excess mucus production. The infection can then spread down the throat, bronchi and lungs. The common cold (one of the most common ailments in humans, also known as non-allergic rhinitis, viral upper respiratory infection, viral URI) is a contagious infectious disease that h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395C07K16/18C07K16/26C07K16/44A61K41/00A61P11/00
CPCA61K41/0004A61K2039/505A61K2039/507C07K16/26C07K16/44C07K16/18A61P11/00A61P11/04A61P11/14A61P31/00A61P31/12A61P43/00A61K39/395A61K39/39533A61K39/39583C07K16/24A61K39/3955
Inventor 奥列格·伊里奇·爱泼斯坦
Owner 奥列格·伊里奇·爱泼斯坦