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Empty capsule suitable for being filled with traditional Chinese medicines

A technology of hollow capsules and traditional Chinese medicines, which is applied in the fields of capsule delivery, pharmaceutical formulations, and medical preparations of non-active ingredients. It can solve the problems of discoloration of medicine powder, loss of water into columns, and brittle capsules, etc., and achieve better water resistance. Toughness, facilitates release and absorption, and improves utilization

Active Publication Date: 2015-04-08
青岛益青生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, in order to develop my country's traditional Chinese medicine industry, the country has entered the "Eleventh Five-Year Plan" period. The "National Medium and Long-term Science and Technology Development Plan (2006-2020)" will "strengthen the inheritance and innovation of traditional Chinese medicine, and promote the modernization and internationalization of traditional Chinese medicine. "Listed as one of the key points of China's scientific and technological development in the future, but the development of domestic TCM dosage forms has been very slow. The big reason is due to the particularity of TCM. Due to its strong water absorption, ordinary pharmaceutical excipients are difficult to meet its use. Therefore, it is of great significance to develop new dosage forms of traditional Chinese medicine and promote the development of traditional Chinese medicine to study a hollow capsule suitable for filling traditional Chinese medicine.
[0003] At present, with the development of traditional Chinese medicine in China, more and more traditional Chinese medicines use capsule preparations. However, due to the low water content of traditional Chinese medicines, the moisture in the filled gelatin hollow capsules migrates into the medicine powder, and the capsules are fragile and the medicine powder is easy to break. Phenomena such as dehydration into columns and discoloration of medicinal powder. Although there are plant capsules that can meet the needs of filling some traditional Chinese medicines, the use of plant capsules has been limited due to their high price and difficult production control.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 90 parts of gelatin, 10 parts of agar, 0.05-0.2 parts of sodium lauryl sulfate, and 0.005-0.10 parts of polyethylene glycol. Stir the above materials evenly, add them to 200 parts of purified water above 90°C, and stir for 1-2 Hours, until all dissolve evenly, at 50-60 ℃ stable for more than 2 hours to form glue, above-mentioned glue can produce the empty capsule with low water content on the full-automatic capsule machine. The water content of the hollow capsule is very low after drying, which is suitable for filling with traditional Chinese medicine.

Embodiment 2

[0021] Take 50 parts of gelatin, 50 parts of agar, 0.05-0.2 parts of sodium lauryl sulfate, 0.005-0.10 parts of polyethylene glycol, and 0.1 part of glycerin. Stir the above materials evenly, and add them to 200 parts of purified water above 90°C. Stir for 1-2 hours until it is completely dissolved and stabilized at 50-60°C for more than 2 hours to form a glue solution. The above glue solution can be used to produce hollow capsules with low water content on a fully automatic capsule machine.

Embodiment 3

[0023] Take 70 parts of gelatin, 30 parts of agar, 0.05-0.2 parts of sodium lauryl sulfate, 0.005-0.10 parts of polyethylene glycol, and 0.08 parts of glycerin, stir the above materials evenly, and add them to 200 parts of purified water above 90 °C, Stir for 1-2 hours until it is completely dissolved and stabilized at 50-60°C for more than 2 hours to form a glue solution. The above glue solution can be used to produce hollow capsules with low water content on a fully automatic capsule machine.

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Abstract

The invention provides an empty capsule suitable for being filled with traditional Chinese medicines. The empty capsule comprises the components in percentage by weight as follows: 49.73-89.9% of gelatin, 10-50% of agar, 0.05-0.25% of plasticizer, 0.001-0.02% of release agent, 0.00-0.002% of pigment, and the balance of water. The empty capsule provided by the invention has the characteristic of low water content, and is suitable for all capsule forms, and in particular suitable for being filled with traditional Chinese medicines. The empty capsule is high in adaptability, and can promote development of traditional Chinese medicines in China and fill the blank of the empty capsule in China.

Description

technical field [0001] The invention relates to the field of medical capsules, in particular to a hollow capsule suitable for filling traditional Chinese medicine. Background technique [0002] In recent years, in order to develop my country's traditional Chinese medicine industry, the country has entered the "Eleventh Five-Year Plan" period. The "National Medium and Long-term Science and Technology Development Plan (2006-2020)" will "strengthen the inheritance and innovation of traditional Chinese medicine, and promote the modernization and internationalization of traditional Chinese medicine. "Listed as one of the key points of China's scientific and technological development in the future, but the development of domestic TCM dosage forms has been very slow. The big reason is due to the particularity of TCM. Due to its strong water absorption, ordinary pharmaceutical excipients are difficult to meet its use. Therefore, it is of great significance to develop new formulations ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/36
Inventor 杨涌刘秀彦
Owner 青岛益青生物科技股份有限公司
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