Tacrolimus ointment

A technology of tacrolimus and ointment, applied in the field of ointment compositions containing tacrolimus, to achieve the effects of good stability, promotion of penetration, and comfortable use experience

Active Publication Date: 2015-03-18
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If tacrolimus is administered systemically, it can cause undesired side effects (such as renal dysfunction) and the risk of infection from diseases that are normally prevented by the immune system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1, 0.3 parts of tacrolimus, 150 parts of stearic acid, 150 parts of castor oil, 100 parts of liquid paraffin, 20 parts of triethanolamine, 60 parts of glycerin, 420 parts of distilled water, 40 parts of lauryl methyl sulfoxide , 40 parts of oleic acid, 80 parts of polyvinyl alcohol-124, 30 parts of peppermint oil (all by weight)

[0026] Preparation method: Mix stearic acid, castor oil, and liquid paraffin, and melt on a water bath at 80°C. Separately take triethanolamine, glycerin and distilled water, mix well, heat to the same temperature, slowly add oil phase, stir while adding until emulsification is complete, cool for later use. Separately take lauryl methyl sulfoxide, oleic acid, polyvinyl alcohol-124 and peppermint oil, add finely ground tacrolimus, and stir well. The obtained product is added into the ointment base prepared above while stirring, and the product is obtained.

Embodiment 2

[0027] Example 2, 1 part of tacrolimus, 100 parts of stearic acid, 60 parts of polysorbate 80, 60 parts of liquid paraffin, 100 parts of white petrolatum, 100 parts of glycerin, 5 parts of sorbic acid, 474 parts of distilled water, 20 parts of oleic acid Parts, 30 parts of propylene glycol, 30 parts of polyvinyl alcohol-124, 20 parts of peppermint oil (all by weight parts)

Embodiment 3

[0028] Example 3, 5 parts of tacrolimus, 100 parts of paraffin, 100 parts of white petrolatum, 150 parts of glyceryl monostearate, 150 parts of liquid paraffin, 20 parts of polysorbate 80, 10 parts of ethylparaben, 300 parts of distilled water Parts, 45 parts of decyl methyl sulfoxide, 55 parts of laurocapam, 45 parts of polyvinyl alcohol-124, 30 parts of peppermint oil (all by weight)

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PUM

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Abstract

The invention provides a tacrolimus ointment composition and a preparation method of the tacrolimus ointment composition. The tacrolimus ointment composition provided by the invention has enhanced permeability and reduction of skin irritation, and can be used for the treatment of atopic dermatitis.

Description

technical field [0001] The invention relates to an ointment composition containing tacrolimus. The novel ointment compositions of the present invention are useful as skin topical delivery systems for the treatment of atopic dermatitis. technical background [0002] Atopic dermatitis (AD, also known as atopic eczema) is a chronic, relapsing, inflammatory skin disease characterized by severe itching. related to abnormal immune function. Due to the lack of effective treatment methods, it has a great impact on the quality of life of patients, and its incidence is increasing, so it has become a research hotspot in recent years. In the past 40 years, topical corticosteroids have become the main treatment for AD, but these drugs have obvious limitations in the treatment of AD. Long-term use can easily lead to adverse reactions such as skin atrophy and thinning, telangiectasia, etc., so it is limited to short-term treatment, and Hormone preparations cannot be used on the face and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/44A61K47/32A61K47/20A61K47/12A61K47/24A61K31/436A61P17/00A61P37/06
Inventor 付劼张新明尤斌
Owner JIANGSU SEMPOLL PHARMA
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