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Pharmaceutical composition comprising loperamide or hydrochloride thereof and preparation method thereof

A technology of loperamide and composition, which is applied in the field of medical technology preparation and can solve problems such as lack of instructions

Inactive Publication Date: 2013-08-14
BEIJING KEYUAN CHUANGXIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the instructions of loperamide hydrochloride granules published by Japan’s independent administrative agency Pharmaceuticals and Medical Devices Comprehensive Management Agency, it is mentioned that its prescription consists of refined white sugar, magnesium aluminosilicate, hydroxypropyl cellulose, and cross-linked carboxymethyl cellulose Sodium sodium, silicon dioxide, magnesium stearate, spices, etc., but there is no description or hint that when loperamide hydrochloride is prepared by a common formulation method, in the prepared preparation, hydrochloric acid as an active ingredient Loperamide breaks down significantly over time

Method used

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  • Pharmaceutical composition comprising loperamide or hydrochloride thereof and preparation method thereof
  • Pharmaceutical composition comprising loperamide or hydrochloride thereof and preparation method thereof
  • Pharmaceutical composition comprising loperamide or hydrochloride thereof and preparation method thereof

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Embodiment 1

[0026]

Embodiment 2

[0028]

Embodiment 3

[0030]

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Abstract

The invention discloses a stable granular pharmaceutical composition comprising loperamide or hydrochloride thereof. The pharmaceutical composition also comprises an adhesive which has the effect of stabilizing the loperamide or hydrochloride. Meanwhile, the invention discloses a method for preparing the stable granular pharmaceutical composition. The granular pharmaceutical composition also can serve as a medicine which is in clinical urgent need of development and has a good effect on children acute dysentery.

Description

technical field [0001] The invention belongs to the field of medical technology preparation, and in particular relates to a stable granular pharmaceutical composition formed by using loperamide or its hydrochloride and a specific binder and a preparation method thereof. Background technique [0002] Loperamide hydrochloride is as shown in the following structural formula (I): [0003] [0004] Structural formula (I) which is chemically known as N,N-dimethyl-α,α-diphenyl-4-(p-chlorophenyl)-4-hydroxy-1-loperamide hydrochloride, Its chemical structure is similar to that of haloperidol and pethidine, but the therapeutic dose has no effect on the central nervous system, and its effect on intestinal smooth muscle is similar to that of opioids, which can inhibit the contraction of intestinal smooth muscle and reduce intestinal peristalsis; it can reduce intestinal wall Nerve endings release acetylcholine, which directly inhibits peristaltic reflex through the local interaction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/36A61K47/34A61P1/12A61P31/04A61K31/451A61K47/32A61K9/16A61K47/26A61K47/10
CPCY02A50/30
Inventor 李晓红
Owner BEIJING KEYUAN CHUANGXIN TECH
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