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Antineoplastic traditional Chinese medicine composition and preparation method thereof
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A composition and anti-tumor technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as toxic side effects, leukopenia, tissue necrosis, etc.
Active Publication Date: 2015-04-22
江苏铂康生物科技有限公司
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Embodiment 1
[0029] Weigh 150g of Polygonum cuspidatum, 150g of turmeric, 40g of cinnamon, extract 2 times with 10 times the amount of 90% ethanol, 2 hours each time, combine the alcohol extracts twice, and filter; Add 10 times of water to decoct twice, each time for 1.5h, combine the water extracts, and filter;
[0030] Ethanol is recovered from the alcohol extract; the water extract is concentrated to a relative density of 1.0766, centrifuged at a speed of 3000r / min;
[0031] Under the condition of 70°C, the alcohol extraction concentrate and the water extraction concentrate were combined and vacuum-dried to obtain a dry extract;
[0032] The dry extract is crushed, mixed with appropriate amount of sucrose and dextrin, and ethanol is used as a wetting agent, granulated, dried, and sized to obtain granules.
Embodiment 2
[0034] Weigh 300g of Polygonum cuspidatum, 300g of turmeric, 80g of cinnamon, extract twice with 12 times the amount of 50% ethanol, 2 hours each time, combine the two alcohol extracts, and filter; 300g of astragalus, 200g of Codonopsis pilosula, 160g of Ligustrum lucidum, and 80g of licorice combined with dregs Add 10 times of water and decoct twice, the first time for 1.5h, the second time for 0.5h, combine the water extracts, and filter;
[0035] Ethanol is recovered from the alcohol extract; the water extract is concentrated to a relative density of 0.5, centrifuged at a speed of 3000r / min
[0036] Under the condition of 70°C, the alcohol-extracted concentrated solution and the water-extracted concentrated solution were vacuum-dried separately to obtain a dry extract;
[0037] The dry extract is pulverized, mixed uniformly, mixed with appropriate amount of sucrose and dextrin, and ethanol is used as a wetting agent, granulated, dried and sized to obtain granules.
Embodiment 3
[0039] Weigh 600g of Polygonum cuspidatum, 600g of turmeric, 160g of cinnamon, extract twice with 80% ethanol in 6 times, each time for 3 hours, combine the two alcohol extracts, filter; Add 12 times of water and decoct twice, 2 hours each time, combine the water extracts, and filter;
[0040] The ethanol is recovered from the alcohol extract; the water extract is concentrated to a relative density of 0.8, centrifuged at a speed of 4000r / min;
[0041] Under the condition of 70°C, the alcohol extraction concentrate and the water extraction concentrate were combined and vacuum-dried to obtain a dry extract;
[0042] The dry extract is crushed, mixed with appropriate amount of sucrose and dextrin, and ethanol is used as a wetting agent, granulated, dried, sized to obtain granules, and compressed into tablets.
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Abstract
The invention belongs to the field of traditional Chinese medicines, and in particular relates to an antineoplastic traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-60 parts of Astragalus mongholicus, 10-60 parts of Polygonum cuspidatum, 10-60 parts of rhizoma curcumae longae, 8-40 parts of Codonopsis pilosula, 6-24 parts of glossy privet fruit, 2-16 parts of cinnamon and 2-16 parts of liquorice. The invention also discloses a preparation method of the traditional Chinese medicine composition which comprises the following steps of: extracting the Polygonum cuspidatum, rhizoma curcumae longae and cinnamon with ethanol, filtering and recovering the ethanol; combining dregs of a decoction with the other medicines and adding water for extracting, filtering and concentrating; and combining the recovered ethanol and a water extraction concentrated solution, and drying to obtain a dry extract. The traditional Chinese medicine composition disclosed by the invention is a new tumor angiogenesis inhibitor, can be used for treating cancer patients or adjuvant therapy of the cancer patients, can increase the effect and reduce poisonousness when being matched with chemoradiotherapy, can eliminate immunosuppression caused by chemoradiotherapy toxic and side effects, and can prevent the transferring and spreading of cancer cells after the treatment for patients of operation and chemoradiotherapy.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to an anti-tumor Chinese medicine composition; in addition, the invention also relates to a preparation method of the Chinese medicine composition. Background technique [0002] Tumor is a new organism formed by the body under the action of various carcinogenic factors when a certain cell in a local tissue loses its normal regulation of its growth at the gene level, resulting in abnormal clonal proliferation. We call metastatic and invasive malignant tumors cancer. The latest tumor research has confirmed that cancer is actually a vascular network, and tumor angiogenesis is the central event for malignant tumors to have malignant proliferation. Without the tumor's own blood vessels, there would be no tumor, and without the tumor's own blood vessels, there would be no metastasis. [0003] At present, cancer is the number one killer threatening human life and ...
Claims
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