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Mass detection method for motherwort grains

A quality detection method and granule technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of no content determination and detection items, difficulty in controlling the quality of Yimu granules, etc., and achieve the goal of improving quality control standards and high quality standards Effect

Inactive Publication Date: 2013-08-14
KUNMING CHINESE MEDICINE FACTORY
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AI Technical Summary

Problems solved by technology

In the existing quality control methods of Yimu Granules, there is no TLC identification, and no content determination and testing items, so it is difficult to control the quality of Yimu Granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] (2) Preparation of the reference substance solution: take an appropriate amount of stachydrine hydrochloride reference substance, weigh it accurately, add 70% ethanol to make a solution containing 0.3mg per 1ml, and obtain it;

[0019] (3) Preparation of the test solution: Take the content of this product under the item of difference in loading amount, grind it finely, take about 4.5g or 1g of sucrose-free type, accurately weigh it, put it in a stoppered Erlenmeyer flask, and accurately add 70 % ethanol 25ml, plugged, weighed, ultrasonic treatment for 1.5 hours, ultrasonic treatment power 180W, frequency 35kHz, let cool, weigh again, make up the lost weight with 70% ethanol, shake well, filter, take continued The filtrate is obtained;

[0020] (4) Determination method ： Accurately draw 5 μl and 10 μl of the reference substance solution and 10 μl of the test solution respectively, inject it into the liquid chromatograph, measure it, and calculate it with the logari...

Embodiment 2

[0023] The quality testing method of Yimu Granules is as follows:

[0024] 1) Identification: Take 40g of Yimu granule or 10g of sucrose-free type, grind it, add 250ml or 100ml of ethyl acetate, ultrasonicate for 60 minutes, filter, evaporate the filtrate to dryness, add 1ml of ethyl acetate to dissolve the residue, and use it as the test In addition, take 0.2g of the reference medicinal materials of Angelica sinensis and Rhizoma Chuanxiong, add 20ml of ethyl acetate each, and prepare the reference medicinal material solution in the same way; according to the thin-layer chromatography test, absorb 10-15 μl of the test product solution and 5-10 μl of the reference medicinal material solution , were respectively spotted on the same silica gel G thin-layer plate, developed with n-hexane-ethyl acetate in a volume ratio of 3:1, developed, taken out, dried, and inspected under a UV lamp at 365nm. , showing fluorescent spots of the same color at the position corresponding to the chro...

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Abstract

The invention provides a mass detection method for motherwort grains. The mass detection method comprises the steps of identifying, and measuring the content of motherwort, namely (1) carrying out a chromatograph condition and system suitability test, (2) preparing a reference solution, (3) preparing a test solution, and (4) measuring to ensure that the motherwort content per bag is not less than 10.0mg based on stachydrine hydrochloride (C7H13NO2.HCl). With the adoption of the mass detection method for the motherwort grains provided by the invention, the mass control standard of the motherwort grains is improved, a content determination detection index and a detection method of a main drug, namely motherwort, in a preparation are established, and a thin-layer chromatography qualitative identification method for angelica sinensis and ligusticum wallichii is added, so that the high mass standard level of the compound preparation is guaranteed.

Description

technical field [0001] The invention relates to the technical field of drug quality control, in particular to a quality detection method for Yimu Granules. Background technique [0002] Yimu granule is a medicine for treating women's diseases. Its prescription is: Motherwort 480g, Angelica 240g, Chuanxiong 120g, and Muxiang 45g. Motherwort is the dry aerial part of Leonurus japonicus Houtt., a plant of the Labiatae family, which has the effects of promoting blood circulation, regulating menstruation, diuresis, reducing swelling, and detoxifying sores; Angelica is the dry root of Angelica sinensis (Oliv.) Diels. The effect of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain; Ligusticum chuanxiong is the dried rhizome of Ligusticum chuanxiong Hort. It has the effects of promoting qi and relieving pain, invigorating the spleen and eliminating food. Preparation method of motherwort granules: decoct motherwort with water twice, the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
Inventor 朱敏孙蓉
Owner KUNMING CHINESE MEDICINE FACTORY
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