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Quality control method of Chinese medicine preparation for menstruction regulating and pain relieving

A quality control method and technology of traditional Chinese medicine preparations, applied in non-central analgesics, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as difficult product quality control

Inactive Publication Date: 2007-06-27
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention aims at the shortcomings of the original Tongjingning syrup quality control standard is simple, the product quality is not easy to control, the quality control method of the preparation is studied, the determination of the content of paeoniflorin in Radix Paeoniae Alba, and the thin Layer identification project, improve the quality control standard of Tongjingning preparation, thus ensuring the clinical efficacy of the preparation

Method used

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  • Quality control method of Chinese medicine preparation for menstruction regulating and pain relieving
  • Quality control method of Chinese medicine preparation for menstruction regulating and pain relieving
  • Quality control method of Chinese medicine preparation for menstruction regulating and pain relieving

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0222] Embodiment 1 of the present invention: the quality control method of Tongjingning capsules comprises:

[0223] Properties: Its content is light yellowish brown to brown granules, with little gas and slightly bitter taste.

[0224] Identification: (1) Take 10g of the contents of the capsule, add 50ml of ether, extract under reflux for 30 minutes, discard the ether solution, evaporate the ether from the dregs, add 50ml of ethanol, extract under reflux for 30 minutes, filter, evaporate the filtrate to dryness, add water to the residue 20ml dissolved, extracted twice with water-saturated n-butanol, 20ml each time, combined n-butanol solution, washed with n-butanol saturated water 20ml, dehydrated, n-butanol solution was evaporated to dryness, and the residue was dissolved in 1ml of ethanol, used as Test solution; take another paeoniflorin reference substance, add ethanol to make a solution containing 2mg per 1ml, as the reference solution; according to the Chinese Pharmacop...

Embodiment 2

[0234] Embodiment 2 of the present invention: the quality control method of Tongjingning granule comprises:

[0235] Properties: The product is light yellow to yellow-brown granules; sweet, slightly bitter or slightly bitter.

[0236] Identification: (1) Take 20g of granules, add 80ml of ether, reflux extraction for 40 minutes, discard the ether solution, evaporate the ether from the dregs, add 80ml of ethanol, reflux extraction for 40 minutes, filter, evaporate the filtrate to dryness, add 25ml of water to dissolve the residue , extracted 3 times with water-saturated n-butanol, 30ml each time, combined n-butanol solution, washed with n-butanol saturated water 30ml, dehydrated, n-butanol solution was evaporated to dryness, and the residue was dissolved in 2ml ethanol as the test sample solution; take another paeoniflorin reference substance, add ethanol to make a solution containing 3mg per 1ml, as the reference substance solution; according to the Chinese Pharmacopoeia TLC te...

Embodiment 3

[0246]Embodiment 3 of the present invention: the quality control method of Tongjingning tablet comprises:

[0247] Properties: Light yellow-brown to tan after removing the coating; slight gas, slightly bitter taste.

[0248] Identification: (1) Take 10g of the tablet after removing the coating, add 120ml of ether, extract by reflux for 50 minutes, discard the ether solution, evaporate the ether from the dregs, add 120ml of ethanol, extract by reflux for 50 minutes, filter, and evaporate the filtrate to dryness , the residue was dissolved in 30ml of water, extracted 4 times with water-saturated n-butanol, 40ml each time, the n-butanol solution was combined, washed with n-butanol saturated water 40ml, the water was removed, the n-butanol solution was evaporated to dryness, and the residue was dissolved in 4ml of ethanol , as the test solution; take another paeoniflorin reference substance, add ethanol to make a solution containing 4mg per 1ml, as the reference substance solution...

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Abstract

The quality control method for menstruation regulating and pain relieving Chinese medicine preparation includes partial or all the items of character identification and content measurement. The identification includes the thin layer chromatographic identification of white peony root, licorice and corydalis tuber in the preparation; and the content measurement is to measure the content of white peony root and penoniflorin in the preparation. Compared with available technology, the present invention has increased thin layer chromatographic identification of white peony root, licorice and corydalis tuber and content measurement of penoniflorin, and possesses high precision, high reproducivity, high stability, high recovery rate, accurate measurement and capacity of raising the quality of menstruation regulating and pain relieving Chinese medicine preparation.

Description

Technical field: [0001] The invention relates to a quality control method of a traditional Chinese medicine (Tongjingning) preparation for regulating menstruation and relieving pain, and belongs to the technical field of quality control of medicines. Background technique: [0002] Dysmenorrhea refers to women's periodic lower abdominal pain that occurs during menstruation or before and after menstruation, also known as abdominal pain during menstruation. It is a common and frequently-occurring disease in gynecology, with complex etiology and easy recurrence. With the progress of society, the status of women in society is increasing, the pressure of work and study is increasing, the incidence of dysmenorrhea remains high, and even shows an increasing trend, seriously affecting women's work, study and physical and mental health. Modern medicine believes that dysmenorrhea is related to uterine excessive contraction, uterine ischemia and hypoxia caused by endocrine factors, psy...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61K9/00A61K9/16A61K9/20A61K9/48A61P15/00A61P29/02G01N30/90G01N30/02
Inventor 叶湘武唐修静朱亭潘
Owner GUIZHOU YIBAI PHARMA CO LTD
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