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Quality control method of yinzhihuang preparation

A quality control method, Yinzhihuang's technology, is applied in pill delivery, measuring devices, and pharmaceutical formulations, and can solve problems such as simple and difficult quality control standards and difficult preparation processes

Inactive Publication Date: 2008-09-17
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the chewable tablet needs to be chewed and swallowed, its taste is particularly important, and it is not easy to adopt the general coating process to prevent moisture, so its preparation process has certain difficulties
In addition, the quality control standard of the existing Yinzhihuang preparation is simple, and the product quality cannot be fully and effectively controlled, thereby affecting its clinical efficacy

Method used

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  • Quality control method of yinzhihuang preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Embodiment 1 of the present invention: capillary extract 30g, Gardenia jasmine extract 16g, baicalin 100g, honeysuckle extract 20g, mannitol: sucrose: the mixture of starch=3: 1: 1 (weight ratio), stevia, Citric Acid, Magnesium Stearate

[0127] Get the fine powder mixing of capillary extract, gardenia extract, baicalin and honeysuckle extract, add mannitol in the weight ratio of raw material: filler = 1: 2: sucrose: starch = 3: 1: 1 (weight ratio ), then add 3‰ stevia and 1‰ citric acid, mix evenly, moisten the soft material with 90% ethanol, granulate with 20 mesh screen, dry at 50-60°C, granulate with 16 mesh sieve, fine powder Add 0.4% magnesium stearate, mix thoroughly, compress into tablets, and coat with film. This product is chewable, 4 tablets at a time, 3 times a day.

Embodiment 2

[0128] Embodiment 2 of the present invention: capillary extract 50g, gardenia extract 5g, baicalin 60g, honeysuckle extract 50g, mannitol: sucrose: the mixture of starch=1: 5: 0.5 (weight ratio), stevia, Citric Acid, Magnesium Stearate

[0129]After taking capillary extract, gardenia extract, baicalin and honeysuckle extract and mixing evenly, add the mixture of mannitol: sucrose: starch = 1: 5: 0.5 according to the ratio of raw material: auxiliary material = 3: 1, and then add 10 ‰ stevioside and 5‰ citric acid, mixed evenly, moistened with 50% ethanol to make soft material, granulated, dried, granulated, fine powder added 0.1% magnesium stearate, mixed evenly, compressed, film-coated Made into chewable tablets. This product is chewable, 4 tablets at a time, 3 times a day.

Embodiment 3

[0130] Embodiment 3 of the present invention: capillary extract 10g, gardenia extract 40g, baicalin 150g, honeysuckle extract 10g mannitol: sucrose: starch=10: 0.5: 5 (weight ratio) mixture, stevia, citrus Citric Acid, Magnesium Stearate

[0131] After taking capillary extract, gardenia extract, baicalin and honeysuckle extract and mixing evenly, add the mixture of mannitol: sucrose: starch = 10: 0.5: 5 according to the ratio of raw material: auxiliary material = 0.5: 5, and then add 1 ‰ stevioside and 0.5‰ citric acid, mixed well, 95% ethanol to moisten the soft material, granulate, dry, granulate, add 1% magnesium stearate into the fine powder, mix well, press tablet, film-coated Made into chewable tablets. This product is chewable, 4 tablets at a time, 3 times a day.

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Abstract

The invention provides a quality control method for anti-hepatitis-jaundice preparation, the anti-hepatitis-jaundice preparation is made of artemisia capillaris extraction, gardenia extraction, and baicalin and honeysuckle extraction; compared with the prior art, the quality control method has the advantages of high precision, good reproducibility, high recovery, improvement of the quality control standard of the anti-hepatitis-jaundice preparation, and ability to ensure the clinical effect of the preparation.

Description

[0001] This application is a divisional application of the invention patent application filed by the applicant on June 16, 2006 with the title: "Yinzhihuang preparation and its preparation method and quality control method" and the application number: 2006102005772. Technical field: [0002] The invention relates to a quality control method of Yinzhihuang preparation, which belongs to the technical field of traditional Chinese medicine. Background technique: [0003] Yinzhihuang preparation clears heat and detoxifies, dampness and jaundice, has the effect of reducing jaundice and reducing alanine aminotransferase; it is used for acute, persistent, chronic hepatitis and severe hepatitis (type I) caused by damp-heat toxins, and can also be used Comprehensive treatment for other types of severe hepatitis. The market demand for Yinzhihuang preparations is very large. At present, the main dosage forms include oral liquid and injection, but there is no literature report or product...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/16A61K9/20A61K9/48G01N30/90G01N30/02A61P1/16
Inventor 叶湘武江帆张羽斌潘婷杨坤闫文超
Owner GUIZHOU YIBAI PHARMA CO LTD
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