Application of mepyramine maleate in preparing drug for treating or preventing influenza virus

A kind of pyramine maleate, influenza prevention technology, applied in the field of medicine, can solve the problem of no pyramine maleate application and the like
CN103251591BInactive Publication Date: 2014-12-17WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Publication Date
2014-12-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of mepyramine maleate in preparing a drug for treating or preventing influenza virus. The application comprises the following steps of: selecting the mepyramine maleate with complete non-toxic concentration for carrying out an antiviral experiment, wherein the result shows that the compound has remarkable antiviral activity and is dose-dependent; analyzing an anti-influenza virus action period of the mepyramine maleate, wherein the result indicates that the mepyramine maleate can be mainly used for inhibiting virus infection early events including virus adsorption, virus entry and the like; and detecting the antiviral activity of the mepyramine maleate to different types and subtypes of influenza viruses, wherein the result shows that the mepyramine maleate can be developed as a novel anti-influenza virus drug, so that a novel way and means is provided for treating the influenza.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and more specifically relates to an application of pyrilamine maleate in the preparation of medicines for treating or preventing influenza virus. Background technique

[0002] Influenza virus is a pathogen that seriously affects human health and can cause influenza. According to the differences in the antigenic and genetic characteristics of the virion nucleoprotein (NP) and matrix protein (M), influenza viruses are divided into three types: A, B, and C, also known as A, B, and C. There are significant differences in the genome structure, polypeptide composition, infectivity and pathogenicity of these three different types of viruses. The whole genome of influenza A virus consists of eight single-stranded negative-strand RNAs of different sizes, named after segment 1 to segment 8, respectively. The total length of the viral genome is about 13.6kb, encoding 10 structural proteins (PB2, PB1, PA,...

Claims

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