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Preparation method of atractylenolide II

A technology of Atractylodes lactone and Atractylodes atractylodes, applied in the field of natural medicinal chemistry, can solve the problems of large amount of reagents, serious pollution, low yield, etc.

Inactive Publication Date: 2013-08-21
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Separation of Angelica lactone II prepared by conventional column, the yield is low, the amount of reagent is large, and the pollution is serious

Method used

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Embodiment 1

[0014] Example 2:

Embodiment 2

[0016] Example 3:

Embodiment 3

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Abstract

The invention discloses a preparation method of atractylenolide II, which is simple in operation and small in pollution. The method comprises the following steps: taking and crushing a bighead atractylodes rhizome raw material, adding a 70-100% methanol solution with an addition amount 5-10 times as large as the amount of the raw material into the raw material, and carrying out ultrasonic extraction on the obtained mixture 2-3 times; after an extracting solution is concentrated, carrying out extraction on the obtained product by using an ethyl acetate solution, collecting extract liquor and recovering a reagent, separating a concentrated solution again by using a high-speed countercurrent chromatograph, carrying out on-line monitoring on the obtained object by using an ultraviolet detector, and carrying out fraction collection and decompressed drying on the obtained product. In the preparation of atractylenolide II implemented by using the method, products are high in purity, and easy to realize industrialization amplification.

Description

technical field [0001] The invention belongs to the field of natural medicine chemistry, and in particular relates to a preparation method of atractylodes lactone II. Background technique [0002] Atractylodes lactone II, CAS73069-14-4, molecular formula C 15 h 20 o 2 , molecular weight 232.3, molecular structure formula is as follows: [0003] . [0004] Atractylodes lactone II is a lactone component in Atractylodes macrocephala, which has the functions of anti-inflammation and inhibiting tumor growth. [0005] The existing methods for preparing Atractylodes lactone II mostly use silica gel column for preparation. For example, in the literature "Chemical Components of Atractylodes Rhizoma Atractylodes Rhizoma and Anti-tumor Experimental Research", the method uses steam distillation to extract the volatile oil of Atractylodes Rhizoma Atractylodes Rhizome, and conventional silica gel column chromatography divides the volatile oil of Atractylodes Rhizome into the most p...

Claims

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Application Information

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IPC IPC(8): C07D307/92
Inventor 苏刘花杨成东
Owner NANJING ZELANG AGRI DEV
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