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Application of borneol in preparation of drug used for inhibiting tumorigenesis

A tumor and borneol technology, applied in the direction of anti-tumor drugs, drug combinations, active ingredients of hydroxyl compounds, etc., can solve problems such as lack

Inactive Publication Date: 2013-08-28
韩德民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these are only accumulated experience, and there is a lack of scientific research on its mechanism of action and pharmacological targets as a drug.
There are no relevant reports on the effect of borneol on tumor formation, especially in squamous cell carcinoma of the head and neck.

Method used

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  • Application of borneol in preparation of drug used for inhibiting tumorigenesis
  • Application of borneol in preparation of drug used for inhibiting tumorigenesis
  • Application of borneol in preparation of drug used for inhibiting tumorigenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 borneol inhibits activation of NFkB signal transduction system

[0026] First, we demonstrate the effect of borneol on the NfKb signaling pathway. Firstly, the target THP1 cells (monocytes) were pretreated with three different dosage forms of borneol preparations for half an hour, and then two different inflammatory stimulators of TNFα (tumor necrosis factor) and LPS (lipopolysaccharide) were used to act on THP1 cells, and observed Activation of key enzymes in signal transduction pathways.

[0027] The borneol monomer (50mM), borneol essential oil (1:3000) and borneol oil (1:3000) were pretreated for half an hour, and the control group was pretreated with the same amount of alcohol (because the above borneol dilution solvents are all alcohol ). Afterwards, the cells were stimulated with 5ng / ml TNFα, and IkBa and phosphorylated IkBa were detected at four time points of 0 minute, 5 minutes, 30 minutes and 60 minutes respectively. The results were as follows...

Embodiment 2

[0040] Embodiment 2 borneol inhibits the formation of head and neck squamous cell carcinoma

[0041] After confirming that borneol can inhibit the activation of NFkB signaling system, the next step is to observe the specific effect of borneol on the occurrence and development of head and neck tumors, and explore the mechanism of action. Since it is observed that the inhibitory effects of the above three different dosage forms of borneol on NFkB are roughly similar, and in order to better control the dosage. In the following experiments, we used borneol monomer as the main drug, and the control group still used the same volume of alcohol.

[0042] First, we selected two head and neck tumor cell lines as the in vitro experimental cells FUDU High (hereinafter referred to as FADU H) and SCC23High (hereinafter referred to as SCC23H). Among them, FADU is a hypopharyngeal carcinoma cell line, and SCC23 is an oral squamous cell carcinoma cell line. Both FADUH and SCC23H are highly m...

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Abstract

The invention discloses application of borneol in preparation of a drug used for inhibiting tumorigenesis. In-depth research on application of borneol is carried out by using biomolecular means, and it is found that borneol exerts an inhibitory effect on a tumor through phosphorylation inhibition of a key protein on an NF-kB signal path of an inflammatory signal factor. Definite pharmacological effects enable application of borneol in inhibition of tumorigenesis to be more accurate; that is to say, borneol can substantially inhibit formation of a tumor in the stage of tumorigenesis, but borneol has no obvious inhibitory effect when the stage of tumorigenesis transits to the stage of proliferation of the tumor. Thus, borneol has remarkable application prospects in preparation of drugs used for inhibiting tumorigenesis, especially drugs for inhibiting formation of head and neck squamous cell carcinoma and activation of an NF-kB signal transduction system.

Description

technical field [0001] The invention relates to the application of borneol in the preparation of drugs for inhibiting tumor formation, and belongs to the technical field of anti-tumor drugs. Background technique [0002] Borneo is a colorless, transparent or white flaky crystal. It is also called borneol because of its jade-like appearance. Historically, my country obtained natural borneol from Borneo and Sumatra, and used "borneol" to show its value. Borneo, commonly known as plant musk, was a tribute with the same reputation as golden crowns and ivory teeth during the Sui and Tang Dynasties. In Tang poems, the famous line "green brocade lichens and red embroidered carpets, covered with dipterocarps and tulips" was used to praise dipteroborneols. Borneo is widely used in traditional Chinese medicine and has extremely high medicinal value and health care function. [0003] The chemical name of borneol is: 1,7,7-trimethylbicyclo[2,2,1]hept-2-ol, the molecular formula is C10...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P35/00
Inventor 韩德民钟琦宁石林臧洪瑞王彤
Owner 韩德民
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