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Bunge auriculate root extractive for preventing renal fibrosis

A kind of technology of renal fibrosis and Baishouwu, applied in medicine, the preparation field of the traditional Chinese medicine composition, can solve the problem that the research of renal fibrosis has not yet been reported etc.

Inactive Publication Date: 2014-11-26
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the research of Baishouwu on the prevention and treatment of renal fibrosis.

Method used

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  • Bunge auriculate root extractive for preventing renal fibrosis
  • Bunge auriculate root extractive for preventing renal fibrosis
  • Bunge auriculate root extractive for preventing renal fibrosis

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Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Step 1, the preparation of Radix Polygoni Multiflori extract of the present invention

[0024] 500 g of Radix Polygoni Multiflori was added with 5000 ml of 95% ethanol to reflux extraction for 3 times, each time for 2 hours, and the extract was dried under reduced pressure at 60° C. to dryness to obtain 112 g of Radix Polygoni Multiflori extract.

[0025] Step 2. Experimental research on the in vivo anti-renal fibrosis effect of the Radix Polygoni Multiflori extract of the present invention

[0026] 1. Test drug

[0027] The anti-renal fibrosis test was carried out using the Radix Polygoni Multiflori extract prepared in step one.

[0028] 2. Experimental animals

[0029] Wiatar rats, male, weighing 200-250 g, were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd. [SCXK (Shanghai) 2008-0016].

[0030] 3. Experimental method

[0031] 3.1 Establishment of renal fibrosis rat model

[0032] Eighty rats were anesthetized by intraperitoneal injection of 10% ...

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Abstract

The invention aims to provide a bunge auriculate root extractive for preventing renal fibrosis as well as a preparation method and a pharmaceutical composition of the bunge auriculate root extractive. The bunge auriculate root extractive has an obvious effect on preventing the renal fibrosis and can be used in drugs for preventing or treating the renal fibrosis. A bunge auriculate root is extracted by 59 % (vol) ethanol, an extracting solution is dried under reduced pressure, and the extractive is prepared. The bunge auriculate root extractive is taken as an active ingredient and mixed with auxiliary materials which are acceptable in pharmacy, so that commonly-used dosage forms such as a tablet, a capsule, a granule, a mixture, an oral solution, a dropping pill, syrup, a tincture, an injection and the like can be prepared. Animal experiments show that the bunge auriculate root extractive can obviously reduce renal indexes and the content of hydroxyproline in renal tissue, inflammatory cells of the renal tissue are obviously reduced, the proliferation degree of fibrous tissue is relieved, renal interstitium collagen is obviously reduced, lesion is substantially improved, and the bunge auriculate root extractive indeed has effects on preventing and treating the renal fibrosis.

Description

technical field [0001] The present invention relates to the new medicine application of the extract of Radix Polygoni Multiflori, in particular to the application of the extract of Radix Polygoni Multiflori and the pharmaceutical composition containing it in the medicine for preventing and treating renal fibrosis, and the invention also relates to the preparation method of the traditional Chinese medicine composition . Background technique [0002] Renal fibrosis refers to the pathological repair response of the kidney under the action of various pathogenic factors such as inflammation and injury, and its essence is the proliferation of fibroblasts, excessive accumulation of extracellular matrix and progressive decline of renal function. Renal fibrosis is the main pathological change of a variety of chronic kidney diseases, and it is a common pathway that eventually leads to end-stage renal failure. Western medicine currently uses hormones, interferon, ACEI, etc. to fight fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/27A61P13/12
Inventor 彭蕴茹丁永芳李友宾
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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