Anal fistula suppository and preparation method thereof
A technology of biological embolism and anal fistula, applied in medical science, prosthesis, etc., can solve the problems affecting the product's anti-infection ability, tissue regeneration ability, product instability, and damage to the three-dimensional structure, so as to increase the DNA removal process and ensure stability and uniformity, low immunogenicity and high effect
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Embodiment 1
[0042] Example 1: Preparation of 4-layer anal fistula bioembolism
[0043] The preparation method is as follows:
[0044] (1) Determination of animal source and pretreatment and initial washing of small intestine tissue
[0045] The Chinese inbred Wuzhishan minipig was selected as the animal source, and the animal species was determined using the method specified in the patent ZL200510008994.2. The small intestine tissue of the freshly slaughtered Chinese inbred Wuzhishan minipig was cleaned, and the small intestinal submucosa was separated and used Rinse with water for injection 3 times.
[0046] (2) Virus inactivation
[0047] Adopt the peracetic acid-ethanol solution method to inactivate the virus, this step is carried out in the constant temperature ultrasonic cleaner that the cleaning tank can vibrate, wherein the volume percentage of peracetic acid is 0.05~0.2% (preferably 0.1%), inactivation The time is 1 to 2 hours (preferably 1 hour), the temperature range is 4 to ...
Embodiment 2
[0056] Embodiment 2: Physical and chemical properties, histology, growth factor and biological performance detection of the material prepared in embodiment 1
[0057] 1. Porosity determination
[0058] Porosity determination: Mercury porosimetry was used to determine the porosity of the material and compared with and compared with Biodesign Surgisis products. Results: The porosity of the sample provided in Example 1 was 87.8±2.51, and the porosity of the Biodesign Surgisis product was 78.3±6.38.
[0059] 2. Chemical performance testing, testing items include virus, pH, endotoxin and DNA residue.
[0060] 1) Test solution preparation: test solution preparation: get the uniform thickness part of the sample, cut into 1cm 2 fragments, washed with water and dried, then added to a glass container, according to the total surface area of the inside and outside of the sample (cm 2 ) to water (mL) at a ratio of 5:1, add water, put the lid on, place in a pressure steam sterilizer, h...
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