Method for preparing lactone through catalyzing oxidation of ketone compound

A ketone compound and a technology for the compound are applied in the field of catalyzing the oxidation of ketone compounds to prepare lactones, which can solve the problems of limited practical application and safety problems, and achieve the effects of simple process, easy separation and good industrial application prospects.

Active Publication Date: 2013-09-04
山东尚正新材料科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent (CN102408404A) reported a method of using oxygen as an oxidant to catalyze the oxidation of cyclohexanone to prepare caprolactone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] In 10 mL of ethyl acetate solution containing 5 mg of hydroxylated multi-walled carbon nanotubes, add 2 mmol of cyclohexanone and 2 mmol of benzaldehyde, feed oxygen, and stir the reaction at a temperature of 25 ° C for 4 hours. After detection and analysis, the cyclohexanone The conversion rate of hexanone was 85%, and the selectivity of ε-caprolactone was greater than 99%.

[0018]

Embodiment 2

[0020] In 10 mL of 1,2-dichloroethane solution containing 10 mg of carboxylated multi-walled carbon nanotubes, add 2 mmol of 4-methylcyclohexanone and 8 mmol of benzaldehyde, and stir the reaction at 120 °C for 5 hours , After detection and analysis, the conversion rate of 4-methylcyclohexanone is 97%, and the selectivity of 4-methylcyclohexanolactone is greater than 99%.

[0021]

Embodiment 3

[0023] In 10 mL of sec-butyl acetate solution containing 10 mg of carboxylated single-walled carbon nanotubes, 2 mmol of 2-adamantone and 6 mmol of benzaldehyde were added, and the reaction was stirred at 30°C for 8 hours. After detection and analysis, 2- The conversion rate of adamantone was 92%, and the selectivity of 2-adamantolactone was greater than 99%.

[0024]

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PUM

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Abstract

The invention discloses a method for preparing lactone through catalyzing the oxidation of a ketone compound. The method which treats the ketone compound as a raw material and carbon nanotubes as a catalyst comprises a step of adding an organic solvent and an assistant, and a step of carrying out a catalysis reaction at 25-120DEG C under normal pressure to obtain a lactone compound in a high selectivity manner. The method has the advantages of simple process, mild condition, high selectivity, safety, easy catalyst recovery and the like.

Description

technical field [0001] The invention relates to a method for preparing lactone, in particular to a method for preparing lactone by catalyzing the oxidation of ketone compounds. Background technique [0002] Lactone is an important intermediate in organic synthesis, such as ε-caprolactone, which is widely used in the synthesis of polycaprolactone (PCL) and blended modified resins for various purposes. At present, in the method for preparing lactones by Baeyer-Villiger oxidation reaction, the oxidants used are usually organic peracids such as peracetic acid, peroxybenzoic acid, etc., and the use of such oxidants is not only costly, but also exists in actual operation. Many potential safety hazards limit the practical application of this process. [0003] Therefore, the preparation of lactones by Baeyer-Villiger oxidation using environment-friendly and safe oxygen / air as an oxidant has attracted much attention. The patent (CN102408404A) reports a method for preparing caprolac...

Claims

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Application Information

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IPC IPC(8): C07B41/12C07D313/04C07D313/10C07D309/30C07C67/42C07C69/14C07C69/24C07C69/78
Inventor 纪红兵陈韶云周贤太陶旺聪
Owner 山东尚正新材料科技股份有限公司
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