Composition of purified soluble mannans for dietary supplements and methods of use thereof

A mannan, composition technology, applied in the field of purified polysaccharide composition, can solve the problem of not correctly identifying low or high insulin foods, etc.

Inactive Publication Date: 2013-09-04
BOSTON THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the authors did not properly identify low or high insulin foods

Method used

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  • Composition of purified soluble mannans for dietary supplements and methods of use thereof
  • Composition of purified soluble mannans for dietary supplements and methods of use thereof
  • Composition of purified soluble mannans for dietary supplements and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] In an illustrative example, a subject suspected of having a pre-diabetic condition is administered a meal containing about 400 kcal of a combination of starch and sugar. The subjects' blood glucose levels were monitored within 2 hours of the meal. Figure 5 A graph of blood glucose levels in a subject according to an exemplary embodiment is described. like Figure 5 As shown, the first data point 500 is the unprocessed case and the second data point 502 is the processed case. In this exemplary embodiment, the subject ingested about 6 g of the purified mannan fiber mixture before a meal. The comparison between the first data point 500 and the second data point 502 clearly shows lower glucose levels during the 2 hours of the test, indicating a reduction in the glycemic index. Therefore, ingestion of about 6 g of the purified mannan fiber mixture resulted in lower glucose levels.

Embodiment 2

[0093]In another illustrative example, a study was conducted comparing the response produced by two test meals containing purified mannan fiber compared to the response produced by a control meal (plain white rice) with an equal portion of carbohydrates short-term postprandial blood glucose and insulin responses. The study used a repeated measures design such that each subject ingested each meal on two separate occasions, completing a total of six separate trial periods. Each subject completed their trial phase on a separate weekday morning as close as possible to a similar time each day when they would normally eat breakfast.

[0094] subject

[0095] exist Image 6 Details about the subjects, including gender, age, body mass index (BMI), and ethnicity, are listed in . like Image 6 shown. Subjects included 10 healthy, non-smoking, overweight or obese subjects (4 women, 6 men). The subjects' mean age ± SD was 29.2 ± 3.3 years (range: 25.6-36.8 years), and their mean bod...

Embodiment 3

[0138] Toxicity test

[0139] In an illustrative embodiment, the purification step described above reduces the level of dioxins to less than 0.01 mg / kg, a level considered safe for human consumption. High levels of PCP and dioxins have been found in certain batches of guar gum sourced from or delivered in India, approximately 1000 times higher than generally considered normal background contamination levels. This contamination poses a threat to public health if steps are not taken to avoid the presence of pentachlorophenol (PCP) and dioxins in guar gum. In an illustrative embodiment, testing has shown that the product or purified mannan fibers of the present invention do not contain more than 0.01 mg / kg of pentachlorophenol (PCP). Similarly, the process is effective against microbial toxins and heavy metals, making the product safe for human and non-human consumption.

[0140] In an illustrative embodiment, the purified mannan fibers of the present invention are tested for h...

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Abstract

A composition of chemically purified soluble mannans from legumes' seeds (e.g. Ceratonia siliqua, Caesalpinia spinosa Trigonelle foenum-graecum, and Cyamopsis tetragonolobus) and their use in the assembly of palatable dietary supplements is disclosed herein. The fractionation process provides high-quality physiologically soluble, chemically modified and purified homogeneous size polysaccharide fibers, devoid of natural impurities, for example proteins, alkaloids, glycoalkaloids, and / or environmental impurities including heavy metals, agricultural residues and microbial toxins. This process provides hypoallergenic dietary fibers devoid of any potential allergens, cytotoxins, and gastrointestinal toxins. A sequential process for assembly of the soluble fibers with plurality of molecular weights to create a time controlled dissolution of the functional high and low molecular weight fibers for improving solubility and palatability with improved dietary performance in the oral and gastro-intestinal system is also disclosed herein.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Patent Application Serial No. 61 / 410,609, filed November 5, 2010, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates to the field of purified polysaccharide compositions. More specifically, the present invention relates to the extraction and purification of compositions for lowering the carbohydrate glycemic index of foods and slowing blood sugar elevations. Background technique [0004] Bean fiber has attracted considerable attention as a natural source of soluble dietary fiber. Beans contain a middle hard yellow germ surrounded by horny and relatively large layers of white, translucent endosperm. The endosperm contains polysaccharides with a mannan backbone containing predominantly galactose side chains. The endosperm is surrounded by a tough, dark brown outer skin. The color of the mucilage pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23G3/20
CPCC08B37/0087A23V2002/00A23V2200/328A23L29/238A23V2250/5116A23L33/26
Inventor 艾利泽尔·祖默尔大卫·普拉特
Owner BOSTON THERAPEUTICS
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