Shuangzotai vaginal expansion suppository and its preparation method and detection method
A vaginal expansive suppository and Shuangzotai suppository technology, applied in suppository delivery, measuring devices, pharmaceutical formulations, etc., can solve the problems of disordered expansion, lower clinical application, no quality control method of Shuangzotai suppository, etc., to prevent outflow , to avoid the effect of secondary infection
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Embodiment 1
[0081] Preparation:
[0082] a. Take semi-synthetic fatty acid glycerides, paraffin and lanolin according to the prescription amount, and place them in a water bath for heating and melting;
[0083] b. add metronidazole, clotrimazole and chlorhexidine acetate under constant stirring and mix uniformly to obtain a mixture;
[0084] c. The mixture in step b is poured into the suppository mold, inserted into the tampon, cooled and shaped to make an egg-shaped suppository.
Embodiment 2
[0086] Composition of expansive suppositories
[0087] Preparation method: make a torpedo-shaped suppository according to the method of Example 1.
Embodiment 3
[0090] Preparation:
[0091] a. Take semi-synthetic fatty acid glycerides, paraffin and lanolin according to the prescription amount, and place them in a water bath for heating and melting;
[0092] b. add metronidazole, clotrimazole, chlorhexidine acetate and carbomer under constant stirring, and mix uniformly to obtain a mixture;
[0093] c. Take the prescription amount of polyethylene glycol 1500, place it in a water bath and heat and melt it;
[0094] d. Stir continuously, add the mixture of step b to step c, and mix evenly to prepare the mixture;
[0095] e. The mixture in step d is poured into a suppository mold, inserted into a tampon, cooled and shaped to make a spherical suppository.
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