Shuangzotai vaginal expansion suppository and its preparation method and detection method

A vaginal expansive suppository and Shuangzotai suppository technology, applied in suppository delivery, measuring devices, pharmaceutical formulations, etc., can solve the problems of disordered expansion, lower clinical application, no quality control method of Shuangzotai suppository, etc., to prevent outflow , to avoid the effect of secondary infection

Active Publication Date: 2014-10-15
哈尔滨田美药业股份有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there are still the following problems to be solved: 1. The sliver in the traditional Shuangzotai suppository has no expansion effect, or the expansion is disordered, which greatly reduces the clinical application; 2. The quality control method is unreliable, resulting in In the actual production process, the content, stability, and melting time between batches vary greatly; although the 2010 edition of the Chinese Pharmacopoeia is more reasonable to use HPLC for the determination of metronidazole, clotrimazole, and chlorhexidine acetate. The controllability of Zoltai suppository, but there is still no quality control method for sliver of Shuangzotai suppository; 3. Simple mixing of multiple compound ingredients cannot exert their respective curative effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Shuangzotai vaginal expansion suppository and its preparation method and detection method
  • Shuangzotai vaginal expansion suppository and its preparation method and detection method
  • Shuangzotai vaginal expansion suppository and its preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Preparation:

[0082] a. Take semi-synthetic fatty acid glycerides, paraffin and lanolin according to the prescription amount, and place them in a water bath for heating and melting;

[0083] b. add metronidazole, clotrimazole and chlorhexidine acetate under constant stirring and mix uniformly to obtain a mixture;

[0084] c. The mixture in step b is poured into the suppository mold, inserted into the tampon, cooled and shaped to make an egg-shaped suppository.

Embodiment 2

[0086] Composition of expansive suppositories

[0087] Preparation method: make a torpedo-shaped suppository according to the method of Example 1.

Embodiment 3

[0090] Preparation:

[0091] a. Take semi-synthetic fatty acid glycerides, paraffin and lanolin according to the prescription amount, and place them in a water bath for heating and melting;

[0092] b. add metronidazole, clotrimazole, chlorhexidine acetate and carbomer under constant stirring, and mix uniformly to obtain a mixture;

[0093] c. Take the prescription amount of polyethylene glycol 1500, place it in a water bath and heat and melt it;

[0094] d. Stir continuously, add the mixture of step b to step c, and mix evenly to prepare the mixture;

[0095] e. The mixture in step d is poured into a suppository mold, inserted into a tampon, cooled and shaped to make a spherical suppository.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a Shuangzotai vaginal expansive suppository. The expansive suppository includes an active ingredient composed of clotrimazole, metronidazole and chlorhexidine acetate, a fat-soluble matrix and an expansive carrier. The drug layer is in full contact with the inner wall of the vagina to prevent the drug liquid from flowing out; the expansion plug is an inner and outer layer expansion plug, and the active ingredient is mixed with different substrates to form two layers, which can achieve dual effects of quick release and sustained release; The Shuangzotai vaginal expansion suppository provided by the present invention adopts seven original leading technologies, and the Shuangzotai vaginal expansion suppository has the functions of preventing the outflow of medicinal liquid, quick effect, long drug action time, and prevention of secondary infection, etc. Beneficial effect.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Shuangzotai vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Shuangzoltai suppository refers to Shuangzoltai suppository containing cotton sliver. The Shuangzoltai cotton suppository released by Shenyang Nuoya Pharmaceutical Factory on May 9, 2003 is made of metronidazole 200g, clotrimazole 160g, and chlorhexidine acetate. 8g, appropriate amount of lanolin, appropriate amount of paraffin, appropriate amount of semi-synthetic fatty acid glyceride. The 2010 edition of the Chinese Pharmacopoeia disclosed the same Shuangzotai suppository. The curative effect of Shuangzotai Suppository has been clinically proven for many years, and it is widely used in gynecological sterilization. However, Shuangzotai Suppository has always had various technical problems, and most of them have been solved. Shuangzotai suppositor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4174A61K9/02A61K47/46A61P15/02G01B5/08G01G17/00A61K31/4164A61K31/155
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap