An anti-tumor targeting complex and a preparation method and applications thereof

A targeting complex, anti-tumor technology, applied in anti-tumor drugs, chemical instruments and methods, hybrid peptides, etc., can solve problems such as insufficient killing of tumor cells and failure to achieve anti-tumor effects
CN103288968AActive Publication Date: 2013-09-11SHANGHAI TONEKER BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI TONEKER BIOTECH
Publication Date
2013-09-11

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Abstract

The present invention provides an anti-tumor targeting complex which is a chemical crosslinked complex CTX-Onc obtained from chlorotoxin and onconase through disulfide bond crosslinking. Compared with existing anti-tumor CTX and Onc mixtures, the anti-tumor targeting complex of the invention shows better anti-tumor effects both at a cellular level and an animal tumor model level, and has good clinical application and development prospects. The invention also provides a method for preparing the complex and applications of the complex in the preparation of antitumor drugs.
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Description

technical field

[0001] The invention relates to the field of biopharmaceuticals related to biochemistry and genetic engineering technology. Specifically, the invention relates to an anti-tumor targeting complex, a preparation method thereof and an application of the targeting complex in tumor treatment. Background technique

[0002] According to statistics from the Ministry of Health, malignant tumors have become the number one cause of death in my country. Conventional therapies for malignant tumors, including surgery, radiotherapy, and chemotherapy, all have certain limitations. For example, traditional anti-tumor drugs usually have relatively large side effects, and while killing cancer cells, they also cause great damage to normal cells. Targeted drugs use targeting molecules specific to tumor cells to specifically direct anti-tumor drugs to tumor cells, so they have higher killing efficiency on tumor cells and lower side effects on normal cells. The focus of pharmaceu...

Claims

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