Separated type multimode fused three-dimensional imaging system

Abstract

The invention discloses a separated type multimode fused three-dimensional imaging system which comprises an X-ray tomography signal acquisition device, a fluorescence excitation tomography signal acquisition device, an auxiliary imaging device, a data processing module and a system control device, wherein the X-ray tomography signal acquisition device acquires X-ray tomography data after emitting X-rays for illuminating an organism; the fluorescence excitation tomography signal acquisition device acquires fluorescence excitation imaging data in the organism after a fluorescence excitation light source is emitted for illuminating the organism; the auxiliary imaging device is used for eliminating interference among different mode measurement; the data processing module performs mode infusion treatment according to the acquired data; structural information of the organism and light source distribution information inside the organism are reconstructed in a three-dimensional manner; and the system control device controls the accurate position of an objective table and precise rotation of a roller under two modes, and obtains multi-angle projection data and camera data.

Description

technical field [0001] The invention belongs to the field of medical molecular imaging, and relates to a multi-mode fusion imaging system, in particular to a three-dimensional imaging system for the mode fusion of separate excitation fluorescence tomography (FMT) and X-ray tomography (CT). Background technique [0002] Medical molecular imaging technology can noninvasively, continuously, in vivo, and early visualize the expression and activity of specific molecules that affect tumor behavior and tumor response to drug treatment, as well as physiological processes, breaking through the traditional imaging technology that can only display the anatomy caused by lesions. Limitations of Structural Change. [0003] Compared with other small animal in vivo molecular imaging equipment, the optical molecular imaging system has many advantages such as high sensitivity, good specificity, intuitive results, fast measurement, and low cost. These advantages make it develop into an ideal ...

AI Technical Summary

Problems solved by technology

With the continuous deepening of molecular imaging research, the widely used planar optical molecular imaging technology cannot perform quantitative three-dimensional imaging of the observed target, and it is increasingly unable to meet the needs of biomedical research.

At the same time, a single optical molecular imaging technology cannot provide comprehensive physiological and pathological information of organisms, and it is difficult to achieve accurate diagnosis of major diseases such as tumors and accurate and effective evaluation of drug efficacy

[0004] Therefore, in recent years, some challenging issues involving multimodal molecular imaging systems and methods have gradually emerged: whether the same imaging system can be used to perform multiple physiological studies on the same organism at the molecular level, functional metabolism level, and anatomical structure level. Imaging and fusion of pathological information? Can the positioning and quantitative data information provided by multimodal molecular imaging be fully utilized in the study of the pathogenesis of major diseases such as tumors? Therefore, it is necessary to integrate multiple modalities of imaging technology to learn from each other's strengths and complement each other's advantages, so as to obtain more comprehensive and complete physiological and pathological information at the anatomical structure level, functional metabolism level and cell molecular level; this has also become the current molecular The new trend in the development of imaging technology is also a very challenging problem

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