Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

testosterone transdermal patch

A testosterone, transdermal technology, applied in non-active ingredients medical preparations, organic active ingredients, sexual diseases, etc., can solve the problems of unsatisfactory transdermal absorption, unstable drug release, easy to fall off, etc. Long-term administration, stable release process, and complete drug release effect

Active Publication Date: 2015-10-21
CHINA RESOURCES ZIZHU PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The testosterone transdermal product prepared by the existing testosterone patch prescription and process has a high content of the main drug per unit area, and has the disadvantages of unsatisfactory transdermal absorption, unstable drug release, easy to fall off or difficult to remove during use, etc. To a large extent, it limits the clinical application of the therapeutic value of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • testosterone transdermal patch
  • testosterone transdermal patch
  • testosterone transdermal patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Mix and dissolve the drug testosterone, penetration enhancer, propylene glycol, and copovidone in ethanol and ethyl acetate; then mix it with acrylic pressure-sensitive adhesive, stir and dissolve evenly, ultrasonicate for 20-30min, and let the drug stand until there are no bubbles. The liquid is evenly coated on the anti-adhesive layer, and after drying at 30°C to 100°C in stages, the solvent is removed, and the backing layer is covered to prepare a testosterone transdermal absorption patch. Its specific prescription composition is as follows:

[0019]

[0020]

Embodiment 2

[0022] The testosterone transdermal absorption patch was prepared by the same method as in Example 1. Its prescription composition is as follows:

[0023]

Embodiment 3

[0025] The testosterone transdermal absorption patch was prepared by the same method as in Example 1. Its prescription composition is as follows:

[0026]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a testosterone transdermal absorbent patch which consists of an anti-sticking layer, a drug-containing glue layer and a liner layer structure, and in particular relates to a compound type modifier formed by the combined action of a plurality of ingredients, so that the skin permeability and the medicine stability of the testosterone can be improved, and the prepared drug-containing glue layer is uniform and stable, more stable in a drug release process, and better in safety. The patch provided by the invention hardly falls off, and is easy to remove, and free from the phenomenon of glue residue during use process, thereby being good in clinic application prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms, and in particular relates to an improved testosterone transdermal absorption patch. Background technique [0002] Testosterone is a male hormone with the chemical name 17β-hydroxyandrost-4-en-3-one. It can be used clinically for testosterone replacement therapy for male hypogonadism. As a hormone supplement drug, long-term medication is generally required. [0003] The patch is a transdermal drug delivery system, and the drug can enter the systemic circulation through three stages: release, permeation and diffusion through the skin, and capillary absorption. Under a certain size and a suitable drug application area, the transdermal rate of the drug in the patch is a key factor to ensure its clinical efficacy. The patch needs to be adhered to the skin for drug administration. Generally, it needs to have good adhesion to ensure that it will not warp and fall off on the skin; i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/10A61K47/34A61K47/14A61K47/18A61K31/568A61P15/08
Inventor 冉勇张艳郑焱刘杰贾君董艳敏冯晓庆张莉
Owner CHINA RESOURCES ZIZHU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com