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New application of recombinant human thymosin alpha collagens

A technology of thymosin and proprotein, applied in the field of recombinant human thymosin alpha proprotein

Inactive Publication Date: 2013-09-18
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] However, there are no reports or patents about prothymosin alpha that can effectively improve the body's anti-fatigue ability.

Method used

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  • New application of recombinant human thymosin alpha collagens
  • New application of recombinant human thymosin alpha collagens
  • New application of recombinant human thymosin alpha collagens

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Embodiment Construction

[0018] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings.

[0019] For the recombinant protein monomer and fusion protein described in the present invention, please refer to the applicant's Chinese Patent 200810072084.4 (A Recombinant Protein in the Preparation of Oral Drugs for Preventing Diabetes) and Chinese Patent 200710009083.0 (A Preparation Method for Anti-tumor Fusion Protein) and its applications).

[0020] Anti-fatigue test of prothymosin alpha monomer and GST-prothymosin alpha fusion protein. Specific steps are as follows:

[0021] ①Choose 4-5 weeks old Kunming rats, divided them into 5 groups, group A, B, C, D, E, and group E blank control group, injected the same volume of PBS, and injected 1 μg / d thymus in groups A and B respectively. Prothymosin alpha monomer and GST-prothymosin alpha fusion protein, groups C and D were injected with 10 μg / d dose of prothymosin alpha monomer and GST-prothymosi...

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Abstract

The invention discloses a new application of recombinant human thymosin alpha collagens, which relates to a recombinant human thymosin alpha collagen. The invention also provides the application of the recombinant human thymosin alpha collagen in preparing anti-fatigue drugs. The recombinant human thymosin alpha collagen (referred to as thymosin alpha collagen) refers to a recombinant human thymosin alpha collagen and a tissue separated and purified thymosin alpha collagen. The effect of the thymosin alpha collagen in various anti-fatigues is implemented through increasing the glycogen storage of the liver and muscles and reducing the level of serum urea nitrogen so as to improve the fatigue resistance.

Description

technical field [0001] The present invention relates to recombinant human thymosin pro-alpha protein, in particular to a new application of recombinant human thymosin pro-alpha protein. Background technique [0002] Prothymosin α (prothymosin α) is a small acidic protein with a relative molecular mass of 12,000, which was originally isolated from rat thymus. Although thymosin is secreted by the thymus, prothymosin α is expressed in many tissues in the body, and it is a conserved DNA sequence without introns. Human prothymosin alpha consists of 109 amino acid residues. It can improve the body's immunity, resist opportunistic infections, promote the maturation and differentiation of lymphocytes, and promote the expression of IL-2 and IL-2R. It also has a certain therapeutic effect on tumors. [0003] In recent years, studies on the etiology and pathogenesis of diabetes have shown that oxidative stress is closely related to the occurrence and development of diabetes (1, Cao W...

Claims

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Application Information

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IPC IPC(8): A61K38/22A61P39/00
Inventor 周克夫罗明
Owner XIAMEN UNIV
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