New application of recombinant human thymosin alpha collagens

A technology of thymosin and proprotein, applied in the field of recombinant human thymosin alpha proprotein

Inactive Publication Date: 2015-01-07
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] However, there are no reports or patents about prothymosin alpha that can effectively improve the body's anti-fatigue ability.

Method used

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  • New application of recombinant human thymosin alpha collagens
  • New application of recombinant human thymosin alpha collagens
  • New application of recombinant human thymosin alpha collagens

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Experimental program
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Embodiment Construction

[0018] The following embodiments will further illustrate the present invention in conjunction with the drawings.

[0019] For the recombinant protein monomer and fusion protein of the present invention, please refer to the applicant's Chinese patent 200810072084.4 (application of a recombinant protein in the preparation of oral medicine for preventing diabetes) and Chinese patent 200710009083.0 (a preparation method of an anti-tumor fusion protein) And its applications).

[0020] Anti-fatigue test of prothymosin alpha monomer and GST-prothymosin alpha fusion protein. Specific steps are as follows:

[0021] ① 4 to 5 weeks old Kunming mice were selected and divided into 5 groups, A, B, C, D, E group, E group blank control group, injected the same volume of PBS, A, B, each group injected 1μg / d thymus Pro-thymosin alpha monomer and GST-pro-thymosin alpha fusion protein, groups C and D were injected with 10μg / d of pro-thymosin alpha monomer and GST-pro-thymosin alpha fusion protein, pro...

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Abstract

The invention discloses a new application of recombinant human thymosin alpha collagens, which relates to a recombinant human thymosin alpha collagen. The invention also provides the application of the recombinant human thymosin alpha collagen in preparing anti-fatigue drugs. The recombinant human thymosin alpha collagen (referred to as thymosin alpha collagen) refers to a recombinant human thymosin alpha collagen and a tissue separated and purified thymosin alpha collagen. The effect of the thymosin alpha collagen in various anti-fatigues is implemented through increasing the glycogen storage of the liver and muscles and reducing the level of serum urea nitrogen so as to improve the fatigue resistance.

Description

Technical field [0001] The present invention relates to recombinant human thymosin alpha protein, in particular to a new use of recombinant human thymosin alpha protein. Background technique [0002] Prothymosinα (prothymosinα) is a small acidic protein with a relative molecular mass of 12,000. It was originally isolated from rat thymus. Although thymosin is secreted by the thymus, prothymosin α is expressed in many tissues in the body, and it is a conservative DNA sequence that does not contain introns. Human thymosin alpha is composed of 109 amino acid residues. It can improve immunity, resist opportunistic infections, and promote the maturation and differentiation of lymphocytes. It can also promote the expression of IL-2 and IL-2R to a certain extent. It also has a certain therapeutic effect on tumors. [0003] In recent years, studies on the etiology and pathogenesis of diabetes have shown that oxidative stress is closely related to the occurrence and development of diabetes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/22A61P39/00
Inventor 周克夫罗明
Owner XIAMEN UNIV
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