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Percutaneous absorption preparation containing rivastigmine

A rivastigmine and preparation technology, applied in the field of percutaneous absorption preparations, can solve problems such as difficulty in obtaining effective efficacy and poor skin penetration, achieve reduced skin irritation, good adhesion and wear performance, and simplify the preparation process Effect

Inactive Publication Date: 2013-09-18
SAMYANG BIOPHARMLS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to this document, the skin penetration amount of the drug of the formulation not containing organic acid salts such as acetates becomes significantly poor, making it difficult to obtain effective potency

Method used

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  • Percutaneous absorption preparation containing rivastigmine
  • Percutaneous absorption preparation containing rivastigmine
  • Percutaneous absorption preparation containing rivastigmine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0061] Examples 1-6: Transdermal preparations for the treatment of dementia containing rivastigmine as an active ingredient agent

[0062] Styrene-isoprene-styrene block copolymer (hereinafter referred to as "SIS") as the binder matrix, polybutene (PB2400, Daelim Petrochemical Company) as the plasticizer, cycloaliphatic Hydrocarbon resin (Kristalex F85, Eastman Chemical Company), aliphatic hydrocarbon resin (Escorez1401, ExxonMobil Chemical) and rosin ester resin (KE311, Arakawa Chemical) were dissolved in the solvent n-hexane to prepare binder solutions.

[0063] To the above adhesive solution was added rivastigmine and an optional skin penetration enhancer in the weight ratio of Table 1. The resulting homogeneous mixture was coated on a siliconized polyester release film, which was then dried at 90° C. for 5 minutes to prepare a sheet having the thickness specified in Table 1. The sheet was laminated with a polyester backing film, and cut to a prescribed size to obtain ...

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Abstract

Disclosed is a percutaneous absorption preparation for treatment of dementia that comprises rivastigmine or its pharmaceutically acceptable salt as an active ingredient, a styrene-isoprene-styrene block copolymer, a tackifier resin, and a plasticizer. The preparation contains a small amount of rivastigmine but allows a sufficient amount of the active ingredient penetrated into the skin to achieve an effective treatment of dementia.

Description

technical field [0001] The present invention relates to a percutaneous absorption preparation comprising rivastigmine as an active ingredient. Background technique [0002] With life expectancy steadily increasing due to advances in medical care and dietary patterns, our world is undergoing rapid transition into an aging society. This global population aging trend has greatly increased the number of older adults requiring long-term care services. Alzheimer's disease is one of the most devastating diseases associated with aging, the most common disease among the elderly in the world, and is known as a degenerative condition that destroys the life of the individual, mostly the family of the individual, causing social problems. [0003] Senile dementia is divided into two categories: Alzheimer's type and vascular dementia. The most common form of senile dementia, Alzheimer's disease, is a central nervous system disorder that begins with memory impairment, progresses to behavi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/27A61P25/28A61P25/00
CPCA61K31/27A61K9/7053A61P25/28A61K9/703A61K47/32A61K47/46A61F2013/00646
Inventor 柳贤硕李荣茂金眩佑金希淑
Owner SAMYANG BIOPHARMLS CORP
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