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Serum separation gel and preparation method thereof

A technology of serum separation gel and polyacrylate, which is applied in the field of serum separation gel, can solve the problems of large gap in quality of serum separation gel, stability of domestic separation gel, poor adhesion and thixotropy, and poor resistance to gamma-rays, etc. , to achieve the effects of easy control of the production process, strong cohesion, and stable product performance

Inactive Publication Date: 2013-10-02
WUHAN SHUTIAN TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the serum separating gels of vacuum blood collection tubes used in large hospitals in my country are products of BD Company in the United States. Although domestic serum separating gels have entered the market, the domestic separating gels have poor stability, adhesion and thixotropy, and are resistant to The γ-ray ability is poor, and the quality level of the serum separation gel of BD company in the United States is far behind, and the market is generally unwilling to accept it.

Method used

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  • Serum separation gel and preparation method thereof
  • Serum separation gel and preparation method thereof
  • Serum separation gel and preparation method thereof

Examples

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preparation example Construction

[0025] A preparation method of serum separating gel, comprising the steps of:

[0026] (1) Add toluene, 2-mercaptoethanol, a 50% by mass mixture of butyl acrylate and ethyl methacrylate, and 0.6 parts of BPO into the flask;

[0027] (2) Stir and heat up. When the temperature reaches 85°C to 90°C, drop the remaining monomer mixture containing 0.6 parts of BPO, butyl acrylate and ethyl methacrylate into the reaction flask from the dropping funnel and keep the temperature 85 ℃ ~ 90 ℃, drop the monomer within 3 hours;

[0028] (3) After continuing to react for 1 hour, lower the temperature to below 70°C to obtain an acrylate copolymer solution;

[0029] (4) The solution was distilled under reduced pressure for 2 hours to remove the solvent toluene and unreacted monomers to obtain a polyacrylate solution;

[0030] (5) Add 5-10 parts of hydrophobic fumed silica and 0-10 parts of diluent DOP to the polyacrylate solution, and stir evenly;

[0031] (6) Vacuum degassing to obtain the...

Embodiment 1

[0033] The invention provides a serum separating gel, which is prepared from the following raw materials in parts by mass:

[0034] Polyacrylate resin 100 parts

[0035] Thixotropic agent hydrophobic fumed silica 3 parts

[0036] The polyacrylate resin described therein is prepared according to the following ratio:

[0037]

[0038] In the polyacrylate serum separation gel, the main performance of the serum separation gel is expressed by polyacrylate. Solution polymerized polyacrylate has the characteristics of low molecular weight, adjustable molecular weight, low viscosity, high monomer conversion rate, and easy control of the preparation process; as the main material, polyacrylate can be copolymerized by monomers of different types and dosage ratios. Its density is close to that of serum separation gel, which just meets the density requirements of serum separation gel; polyacrylate has a large polarity and large intermolecular cohesion energy, and can form a uniform an...

Embodiment 2

[0041] A preparation method of serum separating gel, comprising the steps of:

[0042] (1) A mixture of toluene, 2-mercaptoethanol, 50% mass ratio of butyl acrylate and ethyl methacrylate and 0.6 parts of BPO are added to the flask;

[0043] (2) Stir and heat up. When the temperature reaches 85°C, add the remaining monomer mixture of butyl acrylate and ethyl methacrylate containing 0.6 parts of BPO dropwise from the dropping funnel to the reaction flask, keeping the temperature at 85°C. Drop the monomer within 3 hours;

[0044] (3) After continuing to react for 1 hour, the temperature was lowered to below 70° C. to obtain an acrylate copolymer solution;

[0045] (4) The solution is distilled under reduced pressure for 2 h, and the solvent toluene and unreacted monomers are removed to obtain a polyacrylate solution;

[0046] (5) Add 5 parts of hydrophobic fumed silica to the polyacrylate solution, and stir evenly;

[0047] (6) Vacuum degassing to obtain the product serum sep...

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Abstract

The invention relates to the technical field of preparation of high molecular polymers, and in particular relates to serum separation gel. The prepared serum separation gel appears as a colorless transparent colloid, and has high drawing property, and is at a viscosity of about 1*104cps and a density of 1.050-1.060. The serum separation gel is added to the bottom of a test tube and has no leveling phenomenon when being randomly placed, so that high thixotropy is ensured. When being radiated with a gamma-ray (irradiation dose of 20KGy), the serum separation gel does not generate crosslinking or structuring serious degeneration and has steady anti-irradiation property. While being placed in a blood collection tube for collecting blood and separating blood centrifugally, the serum separation gel can be overturned well to form uniform and transparent separation gel layer between the serum and the blood clot.

Description

technical field [0001] The invention relates to the technical field of high molecular polymer preparation, in particular to a serum separating gel. Background technique [0002] Serum separation gel is a chemically inert, viscous colloid with thixotropy. Its density is about 1.04, which is just between the density of serum and blood clot. Isolation avoids the mutual fusion between blood cells and serum, ensures the stability of blood sample components within a certain period of time, greatly prolongs the storage time of the collected blood samples, reduces the labor intensity of the laboratory technicians, and improves work efficiency. [0003] In 1973, American PECTON Company used silicone oil and silica as raw materials to make a gel and put it on the market in glass test tubes; in 1982, Japan's Sekisui Chemical Industry and its counterparts realized commercialization with plastic test tubes instead of glass test tubes; Silica, vinyl chloride powder prepared serum separat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/08C08K3/36C08F220/18G01N1/34
Inventor 张巧莲张潇潇刘国庆
Owner WUHAN SHUTIAN TECH DEV
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