Preparation method for 9-fluorenylmethoxycarbonyl succinimide

Abstract

The invention specifically discloses a preparation method for 9-fluorenylmethoxycarbonyl succinimide, which belongs to the technical field of synthetic materials. The preparation method comprises the following steps: 1, using fluorenylmethoxycarbonyl chloroformate and an aqueous imidosuccinic acid solution in a mass ratio of 1: 3-4 as raw materials; 2, adding inorganic base in a reaction liquid obtained in step 1 and carrying out a reaction with stirring, wherein the inorganic base is sodium carbonate or sodium bicarbonate, and a mass ratio of the inorganic base to the aqueous imidosuccinic acid solution is 2 to 4; and 3, subjecting a reaction solution obtained in step 2 to filtration, washing and drying so as to obtain 9-fluorenylmethoxycarbonyl succinimide, wherein drying temperature is 30 to 80 DEG C. The preparation process provided by the invention overcomes the problems of low efficiency, low purity and a complex method in conventional processing and synthesis technology and can rapidly and easily process and synthesize 9-fluorenylmethoxycarbonyl succinimide with high purity; meanwhile, the price of equipment used in processing and synthesis is moderate, so needs of middle and small-sized enterprises for processing and synthesis are met, and investment for production cost of the enterprises is reduced.

Description

technical field [0001] The invention relates to the technical field of synthetic materials, in particular to a preparation method for 9-fluorenylmethoxycarbonyl succinimide. Background technique [0002] As we all know, 9-fluorenyl methaneoxycarbonyl succinimide is mainly used in the processing of peptide synthesis products to protect amino acids. It is an organic compound between amino acids and proteins. Through the study of the synthesis process of peptides Discovery has become one of the important research directions in the field of biochemistry. [0003] The existing peptide synthesis generally adopts solid-phase or synthetic methods. On the one hand, the consumption of raw materials is large and the synthesis equipment is expensive, the processing and synthesis efficiency is low, the purity is low, the synthesis reaction process is complicated, and it is not easy to separate; on the other hand, the synthesis The equipment used is expensive, and the production cost is ...

AI Technical Summary

Problems solved by technology

[0003] Existing peptide synthesis generally adopts solid-phase or synthetic methods. On the one hand, the consumption of raw materials during synthesis is large, the synthesis equipment is expensive, the processing and synthesis efficiency is low, the purity is low, the synthesis reaction process is complicated, and it is not easy to separate; on the other hand, the synthesis The equipment used is expensive, and the production cost is high, which cannot meet the needs of small and medium-sized enterprises for processing and synthesis.