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Biphenol compound with anti-tumor activity and pharmaceutical use of compound

A technology for biphenol and antitumor drugs, which is applied in the field of biquinol compounds with antitumor activity and pharmaceutical applications, and can solve the problems of unreported antitumor activity and the like

Inactive Publication Date: 2013-10-30
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We have isolated a new compound from Magnolia officinalis, which has good anti-tumor effect, but there is no report about its compound structure and anti-tumor activity

Method used

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  • Biphenol compound with anti-tumor activity and pharmaceutical use of compound
  • Biphenol compound with anti-tumor activity and pharmaceutical use of compound
  • Biphenol compound with anti-tumor activity and pharmaceutical use of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of formula I compound

[0031] 1. Take 100 kg of Magnolia officinalis medicinal material, crush it into a coarse powder, add 70% ethanol to extract, the amount of ethanol is 8 times of the weight of the medicinal material, each extraction time is 2 hours, and the number of extractions is 3 times.

[0032] 2. Filtrate the extract, combine the filtrates, and concentrate under reduced pressure at 60°C to form an extract.

[0033] 3. Add 10 times the amount of 5% sodium hydroxide solution to the extract, stir to dissolve, let it stand until the solution is clear, filter, then add hydrochloric acid to adjust the pH value to 2-3, stand overnight, filter, and get acid precipitate .

[0034] 3. The acid precipitate was washed with deionized water until neutral, dried and pulverized to obtain the precipitate.

[0035] 4. Take the precipitate, add dichloromethane to reflux and extract, the amount of solvent used is 5 times the weight of the precipi...

Embodiment 2

[0043] Embodiment 2: MTT reduction method detection formula I antitumor activity experiment

[0044] 1. Test drug

[0045] RPMI 1640 medium (Gibco Company), trypsin (Gibco Company); tetramethylazolazolium blue (MTT) (Suzhou Yake Chemical Reagent Co., Ltd.), super newborn bovine serum (Suzhou Yake Chemical Reagent Co., Ltd.) , Dimethyl Sulfoxide (DMSO) (Beijing Chemical Plant)

[0046] 2. Cell lines

[0047] Human gastric cancer cell line SGC-7901, human colon cancer cell line SW-480, human leukemia cell line L1210, human breast cancer cell line MCF-7, human lung adenocarcinoma cell line (SPCA-1) and human liver cancer cell line (BEL-7402 )

[0048] 3. Operation steps

[0049] Human gastric cancer cell line SGC-7901 in logarithmic growth phase, human colon cancer cell line SW-480, human leukemia cell line L1210, human breast cancer cell line MCF-7, human lung adenocarcinoma cell line (SPCA-1) and human Liver cancer cells (BEL-7402) and other 6 cancer cell lines were digest...

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Abstract

The invention relates to a 3'-allyl-5[(1S, 2S)-2,3-dyhydroxyl-1-methoxy propyl]-2,4'-biphenol (formula I) novel compound which is obtained by separating dry tree bark, root bark and twig bark from magnolia biloba (Magnolia officinalis Rehd. et Wils.var.biloba Rehd.et Wils ) of traditional Chinese medicine schisandra sphenanthera mangnolia officinalis (Magnolia officinalis Rehd. et Wils). According to the anti-tumor activity screening research, the 3'-allyl-5[(1S, 2S)-2,3-dyhydroxyl-1-methoxy propyl]-2,4'-biphenol (formula I) has strong anti-tumor activity, and the formula I is shown in the specification.

Description

technical field [0001] The present invention relates to 3'-allyl-5-[(1S,2S)-2,3-dihydroxyl-1-methoxypropyl]-2,4'-biphenol ( Formula I) novel compound and its application in the preparation of antitumor drugs technical background [0002] Tumor is a malignant disease in which cells in local tissues lose their normal growth regulation function at the gene level under the action of various carcinogenic factors, resulting in abnormal proliferation. Malignant tumors are one of the main causes of human death. According to the statistics of the World Health Organization, it is estimated that the annual incidence of global tumors will increase by 50% from 2000 to 2020, eventually reaching 15 million cases per year. Therefore, the prevention and treatment of malignant tumors is very urgent. Screening antineoplastic drugs from natural medicines has always been a hot spot in pharmaceutical research, such as colchicine isolated from Colchicum autumnale L and topoisomerase inhibitor ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/178A61K31/075A61P35/00
Inventor 陈世忠王弘张宝宝
Owner PEKING UNIV
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