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Injectable medicine composition used for resisting cancer

A technology for composition and injection, which is applied in drug combination, antineoplastic drugs, drug delivery, etc., and can solve problems such as reducing injection irritation

Inactive Publication Date: 2013-11-13
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the injection irritation of GC-20 needs to be reduced

Method used

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  • Injectable medicine composition used for resisting cancer
  • Injectable medicine composition used for resisting cancer
  • Injectable medicine composition used for resisting cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Composition prescription:

[0039] components Dosage (grams) GC-20 2 Polyoxyethylene Hydrogenated Stearate 40 Lecithin 10 Mannitol 16 prepared into 100 sticks

[0040] Preparation method: Mix GC-20, polyoxyethylene hydrogenated stearate and lecithin, under the protection of nitrogen flow, slowly add water for injection to 140ml under continuous stirring, add mannitol, dissolve, add water for injection to 200ml, 0.22 After filtering with a μm filter membrane, it is divided into vials and freeze-dried to obtain the product.

Embodiment 2

[0042] Composition prescription:

[0043] components Dosage (grams) GC-20 10 Polyoxyethylene Hydrogenated Stearate 20 glucose 10 prepared into 100 sticks

[0044] Preparation method: Mix GC-20 and polyoxyethylene hydrogenated stearate, under the protection of nitrogen flow, slowly add water for injection to 140ml under continuous stirring, add glucose, dissolve, add water for injection to 200ml, filter with 0.22μm membrane filter Afterwards, it is divided into vials, freeze-dried, and obtained.

Embodiment 3

[0046] Composition prescription:

[0047] components Dosage (grams) GC-20 0.5 Polyoxyethylene Hydrogenated Stearate 4 Lecithin 1 Mannitol 10 prepared into 100 sticks

[0048] Preparation method: Mix GC-20, polyoxyethylene hydrogenated stearate and lecithin, under the protection of nitrogen flow, slowly add water for injection to 140ml under continuous stirring, add mannitol, stir well, add water for injection to 200ml, After filtering through a 0.22 μm filter membrane, it is divided into vials and freeze-dried to obtain the product.

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Abstract

The invention relates to an injectable medicine composition used for resisting cancer. The composition comprises: (i) bis(2,3-bis(tertbutylmethylphosphino)quinoxaline)gold chloride; (ii) a pharmaceutically acceptable injection surfactant; and (iii) a pharmaceutically acceptable lyophilization bracket agent or solvent. A weight ratio of bis(2,3-bis(tertbutylmethylphosphino)quinoxaline)gold chloride to the surfactant is 1:1-1:50. With the composition, the solubility of bis(2,3-bis(tertbutylmethylphosphino)quinoxaline)gold chloride can be increased, and the irritation of bis(2,3-bis(tertbutylmethylphosphino)quinoxaline)gold chloride can be reduced.

Description

technical field [0001] The invention relates to an injectable pharmaceutical composition of an anticancer drug gold complex, in particular to an injectable pharmaceutical application of bis(2,3-bis(tert-butylmethylphosphine)quinoxaline) gold chloride combination. Background technique [0002] Bis(2,3-bis(tert-butylmethylphosphine)quinoxaline) gold chloride (hereinafter referred to as GC-20, the structure is as follows), is a non-platinum metal with multi-target specificity and cytotoxicity The complex is a gold complex that is not yet available in clinical anti-tumor drugs. It has strong anti-tumor effects when taken orally and intravenously. , effective on drug-resistant tumor cells, acute toxicity and preliminary long-term toxicity studies have shown a large therapeutic index and small cumulative toxicity. [0003] [0004] GC-20 chemical structure [0005] GC-20 has low solubility in water and is vascular irritating when administered by injection. The poor water so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K31/675A61P35/00
Inventor 蔡伟惠吴双薛峰金方
Owner SHANGHAI INST OF PHARMA IND CO LTD
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