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New application of isojacareubin

A new technology of brazilian red schicin, applied in medical preparations containing active ingredients, organic chemistry, organic active ingredients, etc., can solve problems such as research reports on the anti-tumor activity of isobrasian red schicin

Inactive Publication Date: 2013-12-04
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the antitumor activity of isobrasinin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 1. Prepare the pure product of isobrasin sclerostin

[0019] a) Nujiang Garcinia Cambogia (collected from Nujiang Prefecture, Yunnan Province in August 2010, the plant sample was identified by Professor Zhou Yuanchuan of Yunnan College of Traditional Chinese Medicine, and the sample was kept in the Innovation Laboratory of Traditional Chinese Medicine of Shanghai University of Traditional Chinese Medicine, labeled G.N.0001) soaked in acetone and extracted , the volume of acetone used for each soak is 5 times the mass of the Nujiang Garcinia cambogia medicinal material to be extracted, soaked for a week each time, and soaked and extracted 3 times in total; the acetone soaked extracts are combined and concentrated under reduced pressure until there is no acetone smell; Using dichloromethane to extract the concentrated solution 4 times, and concentrating the dichloromethane extract under reduced pressure to obtain an extract;

[0020] b) The obtained extract is separated b...

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PUM

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Abstract

The invention discloses a new application of isojacareubin. The new application is meant that isojacareubin as an active ingredient is used in preparation of an antitumor pharmaceutical preparation. Pharmacological tests prove that, isojacareubin has an obvious inhibition effect on growth of U87 human brain glioma cell lines, BXPC-3 human pancreatic cancer cell lines, NCI-2126 human lung cancer cell lines, PANC-1 human pancreatic cancer cell lines, A549 human non small cell lung cancer cell lines, AGs human gastric cancer cell lines, A375 human melanoma cell lines, MCF-7 human breast cancer cell lines, MDA-MB-231 human breast cancer cell lines and SMMC-7721 human liver cancer cell lines, has significant antitumor activity, can be expected to be used as the active ingredient for the preparation of the antitumor pharmaceutical preparation, and has medicinal prospects.

Description

technical field [0001] The invention relates to a new application of isobrazirin schicin, which belongs to the technical field of natural compound application. Background technique [0002] Malignant tumors are currently the main diseases that threaten human health and life. Cancer is the second leading cause of death after cardiovascular disease in most developed countries. Tumor is also a major disease that seriously endangers the health of our people. Our country's tumor research has also been valued by the government. Cancer control has become one of the key points of our country's health strategy. [0003] Tumor treatments include surgery, radiation and chemotherapy. The outstanding problems of the current clinical application of anti-tumor drugs are low efficiency, poor selectivity (high toxicity) and insensitivity to drug-resistant tumors. In addition, recurrence and metastasis are also difficulties in tumor treatment. Therefore, it is a major research topic for p...

Claims

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Application Information

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IPC IPC(8): A61K31/352C07D493/04A61P35/00
Inventor 徐宏喜夏正祥章丹丹劳远至谭红胜刘珍艳
Owner SHANGHAI UNIV OF T C M
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