Method and device for detecting nano particle sizes based on dual-wavelength optical fiber interference method

A nanoparticle and optical fiber interference technology, which is used in measurement devices, particle size analysis, particle and sedimentation analysis, etc., to achieve high-precision identification and analysis, super crosstalk suppression capability, and low noise.

Inactive Publication Date: 2013-12-04
ZHEJIANG UNIV
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Problems solved by technology

[0010] According to the above characteristics, the present invention proposes a micro-optical detection method and device at the scale of nano-biological particles that can be integrated into a microfluidic chip, aiming to effectively solve the problem of rapid size screening and filtration from cells / subcellular to virus levels in biochips, To serve a new generation of smart biochips

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  • Method and device for detecting nano particle sizes based on dual-wavelength optical fiber interference method
  • Method and device for detecting nano particle sizes based on dual-wavelength optical fiber interference method
  • Method and device for detecting nano particle sizes based on dual-wavelength optical fiber interference method

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Embodiment Construction

[0028] The working principle of the present invention is as follows:

[0029] 1. Two beams of light in a conventional Michelson interferometer with phase modulation, signal light E sig and reference light E ref , where E ref or E sig Added the modulation depth as M and the ultrasonic frequency as ω 0 Optical path difference modulation to obtain high-resolution resolution of interference fringes. When only two beams of light interfere,

[0030]

[0031]

[0032]

[0033] In the formula, I is the signal light and reference light interference expression term, I 0 is the intensity of signal light and reference light, is the initial phase of the signal light and reference light interference term, M is the modulation depth, ω 0 to modulate the frequency of the sound wave, is the initial phase of modulation, and t is time.

[0034] The interference signal consists of an even function component 2I 0 cos E(t) and an odd function component 2I 0 sin O(t) are add...

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Abstract

The invention discloses a method and device for detecting nano particle sizes based on a dual-wavelength optical fiber interference method. According to the method, an arc tangent PGC (phase generated carrier) demodulation method is adopted to detect phase shifts when particles pass through, meanwhile, an optical fiber double-interference instrument in wavelength division multiplexing is introduced, two light beams with different wave lengths in one optical fiber are extracted by a split reflector and then are focused to form two closed focused circular cone detection light beams, therefore, two independent phase position detection signals are obtained, difference measurement can be accurately achieved in one optical path to recognize time pulses when nano particles pass through a boundary, the pulse width is relevant to the particle size, accuracy in scattering cross section equivalent diameter measurement on the nano particles can be effectively improved combining with the phase shifts, and single particles with the size as small as 20-40 nanometers can be detected. The method and device for detecting the nano particle sizes based on the dual-wavelength optical fiber interference method have the advantages of being low in noise, high in recognition and analysis accuracy, and strong in crosstalk inhibiting ability.

Description

technical field [0001] The invention relates to a method for detecting the scale of nanoparticles, in particular to a method and a device for detecting the scale of nanoparticles based on a high-resolution dual-wavelength optical fiber interferometry. Background technique [0002] At present, microfluidic chips integrate micro-optic and electronic technologies, and have become the most important development direction of micro-medicine diagnostic and biosensor devices. Many early technologies such as cell sorting or counting, DNA isolation, and pathological diagnosis have been miniaturized through microfluidic technology. As the technology of various functional components in microfluidic chips has become increasingly mature in the past decade, microfluidic-based Lab-on-a-chip is constantly challenging complex functions that are difficult to solve in various medical diagnosis and disease detection methods, such as Detection at the cell level, screening of various disease path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/02
Inventor 吴兴坤黄河陈施洁邹红梅
Owner ZHEJIANG UNIV
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