Novel biodegradable vascular stent preparation method

Abstract

The present invention relates to a novel biodegradable vascular stent preparation method, which specifically comprises: taking a raw material, heating to achieve a melting state, and cooling to a room temperature to obtain a blank material; adopting a self-made mold, a temperature control device, a heating rod, a clamping device, a data acquisition card, a computer monitoring system and other components to form a set of preparation equipment, paving the blank material in the mold cavity, placing the mold in the clamping device after the blank material achieves a set temperature, tightening the clamping device, and carrying out thermal insulation, cooling, mold opening, polishing and cleaning to obtain a primary stent; and placing the stent in an electrostatic spinning device to carry out electrostatic spinning direct-writing to prepare the composite mesh film stent. The prepared stent has characteristics of degradability, smooth surface and substantially increased mechanical strength, wherein a radial strength of the stent can be effectively enhanced and malformation proliferation hyperplasia of vascular endothelium on the stent can be inhibited with the mesh film. In addition, the whole preparation process is easy and easy to performe, and great practical significances are provided for treatment of cadiovascular or lumen stenosis diseases.

Description

technical field [0001] The invention relates to a preparation method of a novel biodegradable vascular stent, belonging to the field of artificial vascular stent preparation. Background technique [0002] At present in our country, the incidence of arteriosclerosis is on the rise, which seriously threatens the health of the people. Arteriosclerosis is a kind of degenerative change and a systemic disease, which is prone to occur in coronary arteries, cardiovascular and cerebral arteries, and peripheral arteries. Diseased artery thickening, hardening, with atheromatous plaque and calcification, and may be secondary to thrombosis. Severe arteriosclerosis directly leads to stenosis, occlusion, and thrombosis of cardiovascular and cerebral arteries and peripheral arteries, resulting in fatal and disabling lesions such as myocardial infarction and ischemic necrosis of limbs. For this reason, modern medicine has carried out the treatment method represented by arterial endoluminal...

AI Technical Summary

Problems solved by technology

[0005] The existing common processes for preparing degradable polymer vascular stents include: polymer silk weaving process, traditional electrospinning and melt extrusion rapid prototyping methods. The vascular stents prepared by these methods have many defects, such as: braiding process: Poor penetration of internal pores, complex process and poor repeatability of preparation of scaffold structure and performance; traditional electrospinning: the formed spinning is at the nanometer level, and it is difficult to achieve on-demand deposition of spinning; melt extrusion is fast Forming: The network structure is realized by layer-by-layer superposition, and the connection strength between layers is insufficient, resulting in an increase in the thickness and cross-sectional area of ​​the scaffold

In addition, there are many deficiencies in the shape accuracy of the bracket, poor surface quality, and mechanical strength.

Images