Novel biodegradable vascular stent preparation method

A vascular stent, biological technology, applied in filament/wire forming, medical science, textiles and paper making, etc., can solve the problem of stent shape accuracy, poor surface quality, mechanical strength, stent thickness and cross-sectional area increase, stent structure Problems such as poor preparation repeatability, to achieve the effect of easy industrial automation, not easy to thrombosis, mechanical strength and volume advantages

CN103432631AActive Publication Date: 2013-12-11SHANGHAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2013-12-11

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Abstract

The present invention relates to a novel biodegradable vascular stent preparation method, which specifically comprises: taking a raw material, heating to achieve a melting state, and cooling to a room temperature to obtain a blank material; adopting a self-made mold, a temperature control device, a heating rod, a clamping device, a data acquisition card, a computer monitoring system and other components to form a set of preparation equipment, paving the blank material in the mold cavity, placing the mold in the clamping device after the blank material achieves a set temperature, tightening the clamping device, and carrying out thermal insulation, cooling, mold opening, polishing and cleaning to obtain a primary stent; and placing the stent in an electrostatic spinning device to carry out electrostatic spinning direct-writing to prepare the composite mesh film stent. The prepared stent has characteristics of degradability, smooth surface and substantially increased mechanical strength, wherein a radial strength of the stent can be effectively enhanced and malformation proliferation hyperplasia of vascular endothelium on the stent can be inhibited with the mesh film. In addition, the whole preparation process is easy and easy to performe, and great practical significances are provided for treatment of cadiovascular or lumen stenosis diseases.
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Description

technical field

[0001] The invention relates to a preparation method of a novel biodegradable vascular stent, belonging to the field of artificial vascular stent preparation. Background technique

[0002] At present in our country, the incidence of arteriosclerosis is on the rise, which seriously threatens the health of the people. Arteriosclerosis is a kind of degenerative change and a systemic disease, which is prone to occur in coronary arteries, cardiovascular and cerebral arteries, and peripheral arteries. Diseased artery thickening, hardening, with atheromatous plaque and calcification, and may be secondary to thrombosis. Severe arteriosclerosis directly leads to stenosis, occlusion, and thrombosis of cardiovascular and cerebral arteries and peripheral arteries, resulting in fatal and disabling lesions such as myocardial infarction and ischemic necrosis of limbs. For this reason, modern medicine has carried out the treatment method represented by arterial endoluminal...

Examples

Embodiment 1

[0028] 1) Calculated from the volume of the stent with a 10% material margin, the amount of material required to calculate the stent is 0.2g, weigh the required amount of PPDO granular material with an electronic scale, and place it on an aluminum alloy that is suitable for the shape of the stent In the alloy mold, heat it with an electric heat gun until it melts, and after cooling, get the PPDO blank;

[0029] 2) A set of preparation equipment is composed of self-made mold, temperature controller, heating rod, 24V power supply, clamping device, pressure sensor, heat-insulating asbestos cloth, data acquisition card, and computer monitoring system. Its line is attached figure 1 connected as shown;

[0030] Pressure temperature Holding time cooling rate pressure 90℃ 10min 3.5℃ / min 5×10 3 N

[0031] 4) Put the mold in the clamping device, set the temperature of the thermostat to 90°C, when the thermostat reaches the set value, place the blank in the...

Embodiment 2

[0035] This example is basically the same as Example 1, except that 0.1g of PLLA is weighed with an electronic scale, dissolved in 1.6ml of trifluoroethanol, stirred and oscillated until completely dissolved, and a concentration of 6.25% (g / ml) of PLLA is obtained. Electrospinning solution; set the fiber spacing of direct-writing electrospinning to 40 μm, and the needle diameter of the barrel is 0.4 mm. By adjusting the computer control system, the voltage is 1 kV, the receiving distance is 0.5 mm, and the feeding speed is 0.2μl / h, the horizontal movement speed of the receiving platform is 150mm / s, and a layer of electrospinning is directly written, and finally a new type of biodegradable vascular stent composited with micron mesh PLLA film is obtained.

Embodiment 3

[0037] This example is basically the same as Example 1, except that 0.1g of PLGA is weighed with an electronic scale, dissolved in 1.6ml of trifluoroethanol, stirred and oscillated until completely dissolved, and a concentration of 6.25% (g / ml) of PLGA is obtained. Electrospinning solution; set the fiber spacing of direct-writing electrospinning to 40 μm, and the needle diameter of the barrel is 0.4 mm. By adjusting the computer control system, the voltage is 1.1 kV, the receiving distance is 0.5 mm, and the feeding speed 0.2μl / h, the horizontal movement speed of the receiving platform is 180mm / s, and a layer of electrospinning is directly written, and finally a new type of biodegradable vascular stent composited with micron mesh PLGA film is obtained.