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Medicine composition of cefpiramide sodium and infant compound amino acid injection (19AA-I)

A kind of technology of cefpiramide sodium and compound amino acid, which is applied in the field of medicine

Inactive Publication Date: 2013-12-25
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In order to overcome a series of problems existing in the prior art, the inventors creatively found the combination of cefpiramide sodium and children's compound amino acid injection (19AA-I), that is, independently packaged cefpiramide sodium sterile powder The cefpiramide sodium powder for injection and the sterilized injection prepared by 19 kinds of amino acids are dissolved and mixed and injected into the body, which not only improves the anti-inflammatory effect, but also reduces the adverse reaction defects of cefpiramide sodium

Method used

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  • Medicine composition of cefpiramide sodium and infant compound amino acid injection (19AA-I)
  • Medicine composition of cefpiramide sodium and infant compound amino acid injection (19AA-I)
  • Medicine composition of cefpiramide sodium and infant compound amino acid injection (19AA-I)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of Cefpiramide Sodium Powder for Injection

[0034] prescription:

[0035]

[0036] making process:

[0037] (1) 250g of cefpiramide sodium sterile powder (in the form of C 25 h 24 N 8 o 7 S 2 (calculated) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0038] (2) 500g of cefpiramide sodium sterile powder (in the form of C 25 h 24 N 8 o 7 S 2 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the lo...

Embodiment 2

[0039] Example 2 Preparation of Pediatric Compound Amino Acid Injection (19AA-I)

[0040] prescription:

[0041]

[0042] making process:

[0043] (1) Add 60L of water for injection into the concentrated preparation tank, and then dissolve each amino acid one by one according to the order of the above formula. After the amino acids are fed and completely dissolved, add 50g of activated carbon and boil for 20 minutes. After 20 minutes of back filtration and decolorization, filter into the diluted preparation irrigation.

[0044] (2) After filtering the concentrated solution into the dilute compounding tank, inject nitrogen gas, add water for injection to the full amount of 90L, slowly add about 10% sodium hydroxide solution to adjust the pH value to 6.4, and add water for injection to the full amount , add 100g of activated carbon and stir for decolorization for 20 minutes, and circulate and filter for 30 minutes.

[0045] (3) After filtering until the visible foreign m...

Embodiment 3

[0046] Example 3 Preparation of Combination Packaged Drugs

[0047] Combination 1: 0.25g of Cefpiramide Sodium Powder for Injection and 100ml of Pediatric Compound Amino Acid Injection (19AA-I).

[0048] Combination 2: Cefpiramide Sodium Powder for Injection 0.25g and Pediatric Compound Amino Acid Injection (19AA-I) 250ml.

[0049] Combination 3: 0.25g of Cefpiramide Sodium Powder for Injection and 20ml of Pediatric Compound Amino Acid Injection (19AA-I).

[0050] Combination 4: Cefpiramide Sodium Powder for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 100ml.

[0051] Combination 5: Cefpiramide Sodium Powder for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 250ml.

[0052] Combination 6: Cefpiramide Sodium Powder for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 20ml.

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Abstract

The invention relates to a medicine composition of cefpiramide sodium and infant compound amino acid injection (19AA-I), and particularly relates to combined application packaging of the medicine composition of the cefpiramide sodium and the infant compound amino acid injection (19AA-I). The medicine composition of the cefpiramide sodium and the infant compound amino acid injection (19AA-I) comprises the cefpiramide sodium for injection and the infant compound amino acid injection (19AA-I). Compared with the mixing use manner of cefpiramide sodium and infant compound amino acid injection (19AA-I), the combined application packaging of the medicine composition has the advantages that steps are simplified, the safety of children medication is improved, the stability of the cefpiramide sodium is greatly benefitted, and the clinical application quality and the biological availability of the medicine are improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition of cefpiramide sodium and children's compound amino acid injection (19AA-I), in particular to the combined application of a sterilized injection prepared from cefpiramide sodium for injection and 19 kinds of amino acids The packaging belongs to the technical field of medicine. Background technique [0002] Cefpiramide sodium has strong antibacterial activity against Gram-positive bacteria and broad-spectrum antibacterial activity against bacteria including Gram-negative bacteria. At the same time, it has strong antibacterial activity against non-glucose fermenting Gram-negative bacteria such as Pseudomonas aeruginosa. And it is stable to β-lactamases produced by various bacteria. It has a strong affinity with 1A, 1B and 3 of penicillin-binding protein (PBP), inhibits the synthesis of bacterial cell walls, and thus exerts a bactericidal effect. Applicable to Staphylococcus aureus, Streptococcus (e...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/08A61P31/04A61P29/00A61P3/02A61K31/185A61K31/195A61K31/198A61K31/401A61K31/405A61K31/4172
Inventor 廖爱国
Owner HAINAN MEIDA PHARMA
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