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Pharmaceutical composition containing ceftizoxime sodium and pediatric compound amino acid injection (19AA-I)

A technology of ceftizoxime sodium and compound amino acids, which is applied in the field of medicine and can solve problems such as slow intravenous injection

Inactive Publication Date: 2013-12-18
HAINAN MEIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In addition, the prior art only mentions in the instructions for use that ceftizoxime sodium for injection can be dissolved in water for injection, sodium chloride injection, and 5% glucose injection for slow intravenous injection, and can also be added to 10% glucose injection, electrolyte Intravenous infusion in injection or amino acid injection for 30 minutes to 2 hours
However, it is necessary to purchase combined application separately in clinical use, and there is no combined package of ceftizoxime sodium for injection and children's compound amino acid injection (19AA-I) on the market or in medical institutions

Method used

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  • Pharmaceutical composition containing ceftizoxime sodium and pediatric compound amino acid injection (19AA-I)
  • Pharmaceutical composition containing ceftizoxime sodium and pediatric compound amino acid injection (19AA-I)
  • Pharmaceutical composition containing ceftizoxime sodium and pediatric compound amino acid injection (19AA-I)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of Ceftizoxime Sodium for Injection

[0034] prescription:

[0035]

[0036] Preparation Process:

[0037] (1) Ceftizoxime sodium sterile powder 500g (in C 13 h 13 N 5 o 5 S 2 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0038] (2) Ceftizoxime sodium sterile powder 1000g (in C 13 h 13 N 5 o 5 S 2 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified ...

Embodiment 2

[0039] Example 2 Preparation of Pediatric Compound Amino Acid Injection (19AA-I)

[0040]prescription:

[0041] Isoleucine

490g

Tyrosine

140g

Leucine

840g

Alanine

320g

Lysine acetate

490g

arginine

730g

Methionine / Methionine

200g

proline

410g

Phenylalanine

290g

serine

230g

threonine

250g

aspartic acid

190g

Tryptophan

120g

glutamic acid

300g

Valine

470g

Glycine

220g

cysteine

＜20g

taurine

15g

Histidine

290g

Water for Injection

Add to 100L

[0042] Preparation Process:

[0043] (1) Add 60L of water for injection into the concentrated preparation tank, and then dissolve each amino acid one by one according to the order of the above formula. After the amino acids are fed and completely dissolved, add 50g of activated carbon and boil for 20 minutes. After 20 minutes of back filtratio...

Embodiment 3

[0046] Example 3 Preparation of Combination Packaged Drugs

[0047] Combination 1: Ceftizoxime Sodium for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 20ml.

[0048] Combination 2: Ceftizoxime Sodium for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 100ml.

[0049] Combination 3: Ceftizoxime Sodium for Injection 0.5g and Pediatric Compound Amino Acid Injection (19AA-I) 250ml.

[0050] Combination 4: Ceftizoxime Sodium for Injection 1.0g and Pediatric Compound Amino Acid Injection (19AA-I) 20ml.

[0051] Combination 5: Ceftizoxime Sodium for Injection 1.0g and Pediatric Compound Amino Acid Injection (19AA-I) 100ml.

[0052] Combination 6: Ceftizoxime Sodium for Injection 1.0g and Pediatric Compound Amino Acid Injection (19AA-I) 250ml.

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Abstract

The invention relates to a pharmaceutical composition containing ceftizoxime sodium and pediatric compound amino acid injection (19AA-I), in particular to a combined application package. The pharmaceutical composition contains ceftizoxime sodium and pediatric compound amino acid injection (19AA-I). Compared with the matching and mixing use of ceftizoxime sodium and pediatric compound amino acid injection (19AA-I), the combined application package has the advantages that the steps are simplified, the pediatric medication security is improved, the stability of ceftizoxime sodium is greatly facilitated, and the clinical application quality and bioavailability of the medicine can be improved.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing ceftizoxime sodium and children's compound amino acid injection (19AA-I), in particular to a combination of sterilized injection prepared from ceftizoxime sodium for injection and 19 kinds of amino acids The application packaging belongs to the technical field of medicine. Background technique [0002] Ceftizoxime sodium is a third-generation cephalosporin with broad-spectrum antibacterial activity and is stable to broad-spectrum β-lactamase produced by most Gram-positive and Gram-negative bacteria. Ceftizoxime sodium has a good antibacterial effect on Haemophilus influenzae and Neisseria gonorrhoeae. [0003] The mechanism of action of ceftizoxime sodium for injection is to achieve bactericidal effect by inhibiting the biosynthesis of bacterial cell wall mucopeptides. It is suitable for lower respiratory tract infection, urinary tract infection, abdominal infection, pelvic infec...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/546A61K31/4172A61K9/08A61P31/04A61P3/02A61K31/198A61K31/401A61K31/405A61K31/185
Inventor 廖爱国
Owner HAINAN MEIDA PHARMA
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