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Traditional Chinese medicine brown ginseng preparation for anti-tumor assistant treatment

An anti-tumor and brown ginseng technology is applied in the field of traditional Chinese medicine brown ginseng preparations to assist anti-tumor, and can solve the problems of limited research on anti-tumor efficacy of total ginseng extract, affecting industrial application, poor absorption in vivo, etc. High content of ginseng polysaccharides and saponins, the effect of inhibiting tumor cells

Inactive Publication Date: 2018-06-01
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Scholars at home and abroad have done many and in-depth studies on the anti-tumor activity of ginsenoside Rg3, and have developed products such as Shenyi Capsules. Problems such as cumbersome processing affect its modern industrial application, and systematic research and development are urgently needed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Extract 300g of brown ginseng, 50g of astragalus, 100g of notoginseng, 100g of ground beetle, 50g of tangerine peel, 100g of bupleurum, 100g of lotus seed extract, and 100g of ganoderma lucidum; reflux extraction with ethanol, and recover ethanol as alcohol extract. The dregs are decocted, filtered, and concentrated to obtain a water extract, which is mixed with the alcohol extract and concentrated to a thick paste with a relative density of 1.30-1.35, dried under reduced pressure, crushed, and an appropriate amount of starch or dextrin is added to the extract powder, and granulated , then add an appropriate amount of magnesium stearate, and press into tablets to obtain 500 finished products.

Embodiment 2

[0035] 270g brown ginseng, 30g astragalus, 70g notoginseng, 80g ground beetle, 30g tangerine peel, 70g bupleurum, 90g lotus seed extract, and 80g ganoderma lucidum; reflux extraction with ethanol, and recover ethanol as alcohol extract. The dregs are decocted, filtered, and concentrated to obtain a water extract, which is mixed with the alcohol extract and concentrated to a thick paste with a relative density of 1.30-1.35, dried under reduced pressure, crushed, and an appropriate amount of starch or dextrin is added to the extract powder, and granulated , then add an appropriate amount of magnesium stearate, and press into tablets to obtain 500 finished products.

Embodiment 3

[0037] Extract 330g of brown ginseng, 80g of astragalus, 130g of notoginseng, 120g of ground beetle, 50g of tangerine peel, 130g of Bupleurum, 110g of lotus seed extract, and 120g of Ganoderma lucidum; reflux extraction with ethanol, and recover ethanol as alcohol extract. The dregs are decocted, filtered, and concentrated to obtain a water extract, which is mixed with the alcohol extract and concentrated to a thick paste with a relative density of 1.30-1.35, dried under reduced pressure, crushed, and an appropriate amount of starch or dextrin is added to the extract powder, and granulated , then add an appropriate amount of magnesium stearate, and press into tablets to obtain 500 finished products.

[0038] Pan, female, 54 years old. On December 12, 2016, he was admitted to our hospital because of "7 and a half years after surgery for stage IIIC ovarian cancer, the anterior lumbar vertebral mass was found for 1 month". The patient underwent total hysterectomy, bilateral adne...

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Abstract

The invention relates to a traditional Chinese medicine brown ginseng preparation for anti-tumor assistant treatment, which includes, by weight, 270-330 g of brown ginseng, 30-80 g of astragalus membranaceus, 70-130 g of panax-notoginseng, 80-120 g of ground beetles, 30-50 g of pericarpium citri reticulatae, 70-130 g of radix bupleuri, 90-110 g of lotus seed extract, and 80-120 g of lucid ganoderma. The brown ginseng is produced in Fusong of the northeast and is mainly planted in low mountains being lower than 300-800 m in elevation. The brown ginseng is suitable for annual average temperatureof 2.4-13.9 DEG C and loves cold and wet weathers. The brown ginseng preparation is simple in preparation method and has no toxic and side effects, can effectively improve postoperative recovery of tumor patient, improves immunity and has inhibition effect on tumors. By replication of an malignant tumor animal model and supplement of pharmacodynamics and toxicologic informations of tumor immunotherapy of special-purpose ginseng polysaccharides and saponins, the preparation can supply evidence for tumor assistant treatment.

Description

technical field [0001] The invention relates to an auxiliary anti-tumor traditional Chinese medicine brown ginseng preparation, which is used in the field of auxiliary anti-tumor traditional Chinese medicine. Background technique [0002] Tumors are a serious threat to human health, but there is a lack of Chinese patent medicines with significant curative effects. Ginseng is rich in polysaccharides and saponins that are of immunotherapeutic significance to tumors, but the shortcomings of low extraction efficiency and poor in vivo absorption performance of traditional ginseng processing methods have not been resolved, which affects the pace of new drug development. In recent years, polysaccharides and saponins in ginseng have become the focus of research and development of new traditional Chinese medicines because of their tumor immunotherapy effects. Scholars at home and abroad have done many and in-depth studies on the anti-tumor activity of ginsenoside Rg3, and have devel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P35/00A61K35/64
CPCA61K35/63A61K36/074A61K36/233A61K36/258A61K36/481A61K36/62A61K36/752A61K2236/333A61K2236/331A61K2236/51A61K2236/39A61K2300/00
Inventor 任辉张道明王丹史莹邹永波赵泽云
Owner JILIN UNIV
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