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Ginseng and astragalus yang-warming vaginal dilation suppository as well as preparation method and detection method thereof

A technology of vaginal expansive suppository and ginseng-warming yang, which is applied in suppository delivery, pharmaceutical formulations, material inspection products, etc. It can solve the problems of poor drug stability, easy-to-contaminate clothes, and no swelling effect of tampons, and achieve fast drug release. , avoid secondary infection, overcome the effect of peak and valley phenomenon

Active Publication Date: 2014-01-08
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The described Shenqi Wenyang suppository has the effect of invigorating the spleen and kidney, warming the yang and stopping leukorrhea, and is used to improve the leukorrhagia caused by spleen and kidney deficiency in married women, and the symptoms such as thin color and white matter; There are not many studies on Wenyang suppositories. Based on the existing technology of Shenqi Wenyang suppositories, there are technical problems of poor drug stability after the raw materials of traditional Chinese medicine are mixed with the matrix, and the active ingredients cannot reach the deep vagina and folds; in addition, the traditional Shenqi Wenyang suppositories The cotton sliver in Wenyang suppository has no swelling effect, or the swelling is disordered, which greatly reduces the clinical application; it is not easy to clean, and it is easy to contaminate the clothes; the quality control method is unreliable, resulting in the actual production process. Technical problems such as large changes in time limit

Method used

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  • Ginseng and astragalus yang-warming vaginal dilation suppository as well as preparation method and detection method thereof
  • Ginseng and astragalus yang-warming vaginal dilation suppository as well as preparation method and detection method thereof
  • Ginseng and astragalus yang-warming vaginal dilation suppository as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110]

[0111] Preparation:

[0112] 1) Preparation of drug-containing matrix:

[0113] a. heating and melting the semi-synthetic fatty acid glyceride in a water bath to obtain a melt;

[0114] b. the preparation of Chinese medicine composition:

[0115] 1 takes by weighing the ginseng of prescription quantity, pulverizes, adds 70% ethanol and refluxes and extracts twice, first time adds alcohol 5 times amount, refluxes 2 hours, second time adds alcohol 3 times amount, refluxes 1.5 hours, filters, merges filtrate, Recover ethanol, concentrate to a clear paste with a temperature of 70°C and a relative density of 1.02, dissolve the clear paste with 5 times the amount of water, put it on a macroporous resin column, and elute with water and 40% ethanol in sequence, and recover the ethanol eluent , concentrated to a thick paste with a relative density of 1.32 at a temperature of 70°C, and spray-dried to obtain fine powder of ginseng extract;

[0116] II Weigh the Fructus Cni...

Embodiment 2

[0122]

[0123] Preparation method: make 100 bullet-shaped suppositories according to the method in Example 1, each weighing about 3.4g.

Embodiment 3

[0125]

[0126] Preparation:

[0127] 1) Preparation of drug-containing matrix:

[0128] a. Polyethylene glycol 400, polyethylene glycol 1500 and polyethylene glycol monostearate are placed in a water bath and heated to melt to obtain a melt;

[0129] b. the preparation of Chinese medicine composition:

[0130] 1 takes by weighing the ginseng of prescription quantity, pulverizes, adds 70% ethanol and refluxes and extracts twice, first time adds alcohol 5 times amount, refluxes 2 hours, second time adds alcohol 3 times amount, refluxes 1.5 hours, filters, merges filtrate, Recover ethanol, concentrate to a clear paste with a temperature of 60°C and a relative density of 1.0, dissolve the clear paste with 7 times the amount of water, put it on a macroporous resin column, and elute with water and 40% ethanol in sequence, and recover the ethanol eluent , concentrated to a thick paste with a relative density of 1.30 at a temperature of 60°C, and spray-dried to obtain fine powde...

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Abstract

The invention relates to a ginseng and astragalus yang-warming vaginal dilation suppository as well as a preparation method and a detection method thereof. The dilation suppository comprises a medicine-containing matrix formed by a Chinese medicine composition and a matrix, and a dilation carrier; the Chinese medicine composition is prepared from ginseng, common cnidium fruit, astragalus and other traditional Chinese medicines; the dilation suppository is a hollow type suppository effervescence vaginal dilation suppository, so that the peak valley phenomenon generated during release of a common suppository is overcome, meanwhile, the stability of the suppository is improved, and the curative effect can reach the depth and wrinkles of the vagina; in addition, the ginseng and astragalus yang-warming vaginal dilation suppository provided by the invention adopts unique six leading technologies and has the beneficial effects of preventing outflow of medicine liquor, preventing secondary infection and the like, and is high in stability, durable in curative effect.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Shenqi Wenyang vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] The State Drug Administration Trial Standard WS-5455 (B-0455)-2002 discloses the quality standard of Shenqi Wenyang suppository, which consists of ginseng 300g, cnidium 600g, astragalus 400g, epimedium 400g, motherwort 300g, diapsis 100g, It is prepared from 100g of saponins, 100g of cassia twigs, 100g of citrus aurantium, 300g of licorice and 1680g of semi-synthetic fatty acid glycerides. The described Shenqi Wenyang suppository has the effect of invigorating the spleen and kidney, warming the yang and stopping leukorrhea, and is used to improve the leukorrhagia caused by spleen and kidney deficiency in married women, and the symptoms such as thin color and white matter; There are not many studies on Wenyang suppositories. Based on the existi...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/02G01N33/15G01N5/04A61P15/00
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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