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Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same

A treatment method and composition technology, applied in the direction of drug combination, skin care preparations, skin diseases, etc., to improve the treatment effect and improve the effect of scars

Active Publication Date: 2014-01-08
金相德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are almost no reports on the use of botulinum toxin for the treatment of scars, especially for the preparation of botulinum toxin into a mixture and injecting it into the skin using a specific method to effectively improve skin scar diseases. no report

Method used

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  • Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same
  • Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same
  • Pharmaceutical composition for treating scars on the skin, and method for treating scars on the skin using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1. Preparation of Compositions Mixed with Botulinum Toxin and Air

[0049] A 0.5 U / CC botulinum toxin solution was prepared by pouring 10 cc of physiological saline into a bottle containing 50 U of botulinum toxin type A1 botulinum toxin. Inject the prepared botulinum toxin solution into the BD Ultra-Fine separately TM II Short Needle Insulin Syringe3 / 10cc31Gx8mm (5 / 16in) syringe, filled with ordinary air in this syringe to prepare a mixture of botulinum toxin and air. At this time, the mixing ratio of botulinum toxin and air was divided into volume ratios of 1:1, 1:2, 1:3, and 1:4, respectively, and prepared.

[0050] In order to compare the scar improvement effect of the above-prepared composition, the ordinary air injection group not containing botulinum toxin and the botulinum toxin injection group not containing air were set as control groups in the following examples.

Embodiment 2

[0051] Example 2. Confirmation of improvement of skin scars

[0052] The composition prepared in Example 1 above (composed by mixing 0.03 cc of botulinum toxin and 0.12 cc of air) was administered to the dermis of 5 patients who actually had scars, and intradermal excision was performed to confirm the extent of the scars. Improve the effect. Intradermal excision is performed once or three times, and the appearance of the skin scar 6 months after the surgery is compared with the skin scar before the surgery.

[0053] show the result in figure 1 with figure 2 .

[0054] Such as figure 1 with figure 2 As shown, as a result of the scar treatment according to the present invention, all patients with skin scars showed significant scar improvement effects, especially only one operation also showed more than 80% treatment satisfaction, thus showing the patient's Satisfaction is very great.

Embodiment 3

[0055] Example 3. Comparison of skin scar improvement effects according to the mixing ratio of botulinum toxin and air

[0056] In order to confirm the improvement effect of the skin scars confirmed with the naked eye in the above-mentioned Example 2 with numerical values, simple air not including botulinum toxin, botulinum toxin not including air, and botulinum toxin and air were compared at 1 : 1, 1: 2 and 1: 3 mixed preparations are injected into the patient's atrophic scars, and the pulsed dye laser and fractional laser are used for treatment. More specifically, in order to eliminate analysis errors due to individual differences in scar recovery ability, 5 depressed scar sites were selected on the left and right faces of one patient ( image 3 ), inject the above-mentioned mixed preparations into the corresponding parts respectively, and quantify the improvement effect of the scars. In order to quantify the degree of improvement of sunken scars, 3D LifeViz II is used to a...

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Abstract

The present invention relates to a pharmaceutical composition for treating scars on the skin, comprising a mixture of botulinum toxin and air. The mixture of botulinum toxin and air according to the present invention, when injected in the dermis, may temporarily suppress the elasticity of the dermis and flatten out the depressed part of the scar, and thus enables elaborate intradermic resection and increases the effects of lasers for treating blood vessels or of fractional lasers. Thus, scars on the skin can be effectively improved through a one-time operation without negatively affecting the daily lives of patients.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for treating skin scars comprising a mixture of botulinum toxin and air and a method for treating skin scars using the same. Background technique [0002] The skin protects body organs from external environmental threats and acts as an automatic thermoregulator to maintain body temperature. The skin is made up of many different layers, each with a specific function. The main layers include the epidermis, dermis, and subcutaneous tissue. The epidermis is a layered layer of epithelial cells covering the dermis, which is composed of connective tissue. Both the epidermis and dermis are further supported by subcutaneous tissue, which is an inner layer of adipose tissue. [0003] The thickness of the epidermis, which is the uppermost layer of the skin, is only 0.1 to 1.5 mm (Inlander, Skin, New York, NY: People's Medical Society, 1-7 (1998)). The epidermis is composed of keratinocytes, which a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K38/17A61K38/48A61K35/74A61K38/46A61P17/02A61P17/00
CPCA61K9/12A61K9/0014A61K38/4893A61K8/64A61K47/02A61K47/26A61Q19/00A61P17/00A61P17/02A61K35/74A61K38/16A61K8/66
Inventor 金相德
Owner 金相德
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