Method for reducing arsenic salt load in water extract of traditional Chinese medicine
A technology for water extract and traditional Chinese medicine, which is applied in the application field of removing arsenic salt load in water extract of traditional Chinese medicine by using strong basic anion exchange resin, can solve the problems of arsenic-free salt removal technology, complex system of traditional Chinese medicine extract, etc. Simple cleaning and regeneration, good arsenic removal, and simple operation
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Embodiment 1
[0022] Example 1 Ion exchange resin removes arsenic salts in rehmannia glutinosa decoction
[0023] Rehmannia glutinosa is a rhizome traditional Chinese medicine that is easily polluted by arsenic salts. This experiment mainly takes raw rehmannia glutinosa (produced in Wenxian County, Henan) as the research object.
[0024] Take 5000g of rehmannia root that has been washed and dried, add 4 times the mass of the medicinal material to decoct for 2 hours, filter through 4 layers of gauze to obtain extract a; then add 3 times the mass of the medicinal material to decoct for 1 hour, filter with gauze to obtain the extract b. Combine the extract a and the extract b to obtain the medicinal solution for later use. Take two parts of 6000ml liquid medicine respectively, concentrate them to 1 / 3 and 1 / 5 times of the original volume by a vacuum concentrator, and mark them as 3 times liquid and 5 times liquid respectively. It is used as the sample to be treated together with the unconcentr...
Embodiment 2
[0042] Embodiment 2 reduces the arsenic content of Chinese medicine compound preparation
[0043] The prescription of Siwu mixture is composed of 4 medicinal materials: angelica, chuanxiong, white peony root and rehmannia glutinosa. Angelica and Rehmannia glutinosa are both susceptible to arsenic salt contamination. The water extract of Siwu mixture was treated with resin to verify the effect of this method on reducing the arsenic load in compound decoction of traditional Chinese medicine.
[0044] According to the preparation method of Zhongsiwu mixture in the 2010 edition of the "Chinese Pharmacopoeia", take 1000g of each of the above four decoction pieces, among which the chuanxiong and angelica are extracted by steam distillation for later use, and the dregs are decocted with white peony root and rehmannia root for 3 Once, the water decoction was combined to obtain a relative density of 1.05-1.10g / cm 3 (65°C) clear paste.
[0045] Weigh D201 strongly basic anion exchang...
Embodiment 3
[0048] Embodiment 3 reduces the arsenic content of Chinese medicine extract
[0049] Take 2 kg of Danshen decoction pieces, add water at 80°C to extract twice, add 10 times the amount of water each time, combine the extracts, concentrate under reduced pressure until the relative density reaches 1.16g / cm 3 (60°C), add 3 times the amount of ethyl acetate to extract three times, combine the extracts, add an appropriate amount of anhydrous sodium sulfate to dehydrate overnight. Concentrate under reduced pressure to form a thick paste, and vacuum-dry at 40°C to obtain the total phenolic acid extract of Salvia miltiorrhiza.
[0050] Take 10 g of salvia miltiorrhiza phenolic acid extract, prepare 5 mg / ml aqueous solution of salvia miltiorrhiza root phenolic acid extract, and weigh D273 strong basic anion exchange resin (purchased from Shanghai Huazhen Technology Co., Ltd.) , were cleaned and activated (same as in Example 1) and loaded into a resin column with a diameter-to-height ra...
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