Preparation method for molecularly imprinted microsphere surface grafted hydrophilic polymer brush

A technology of molecularly imprinted microspheres and hydrophilic polymers, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of expensive and toxic solvents

Inactive Publication Date: 2014-01-15
JIANGSU UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the preparation of imprinted polymers is mostly carried out in organic solvents such as acetonitrile and chloroform. The solvents are exp...

Method used

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  • Preparation method for molecularly imprinted microsphere surface grafted hydrophilic polymer brush
  • Preparation method for molecularly imprinted microsphere surface grafted hydrophilic polymer brush
  • Preparation method for molecularly imprinted microsphere surface grafted hydrophilic polymer brush

Examples

Experimental program
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Effect test

experiment example 2

[0029] Experimental example 2: Take 10 ml of sulfamethazine solution with an initial concentration of 100 μmol / L and add it to a centrifuge tube, add 5.0 mg of imprinted and non-imprinted polymer microspheres after grafting, and put the test solution at 25 o C in a water bath for 5, 10, 20, 30, 45, 60, 90, 120 and 150 minutes. After standing still, the supernatant was collected by centrifugation, and the concentration of unadsorbed sulfamethazine molecules was measured with an ultraviolet-visible spectrophotometer, and the adsorption capacity was calculated according to the results. From Figure 6 It can be seen that, initially, with the increase of contact time, the adsorption amount of sulfamethazine increased rapidly; the hydrophilic non-imprinted polymer microspheres gradually tended to equilibrium after 90 minutes, and the hydrophilic imprinted polymer at 120 Slowly reach equilibrium after a few minutes. In the whole time range, the adsorption amount of sulfamethazine ...

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Abstract

The invention relates to a preparation method for a molecularly imprinted microsphere surface grafted hydrophilic polymer brush, and belongs to the technical field of environment function material preparation. The method comprises the steps of using sulfamethazine as template molecules, using 4-vinylpyridine as a functional monomer, using ethylene glycol dimethacrylate as a cross-linking agent, using methyl alcohol and water as a solvent, using copper bromide/N,N,N',N,'N''-pentamethyldiethylenetriamine/azodiisobutyronitrile as an initiating system to initiate reverse atom transfer radical precipitation and polymerization, so as to prepare the molecularly imprinted polymer microsphere with the surface containing active initiators, using the molecularly imprinted polymer microsphere as the macroinitiator, using cuprous bromide/N,N,N',N',N''-pentamethyldiethylenetriamine as a catalyst, and polymerizing surface initiated atom transfer radical on a molecularly imprinted microsphere surface grafted hydrophilic hydroxyethylmethacylate brush in the methyl alcohol/water mixed solvent. The molecularly imprinted polymer microsphere prepared through the method has higher adsorption capacity, fast adsorption kinetics property and good selective adsorption performance.

Description

technical field [0001] The invention relates to a preparation method for grafting hydrophilic polymer brushes on the surface of molecular imprinted microspheres, and belongs to the technical field of preparation of environmental functional materials. Background technique [0002] Sulfonamides (SAs) have good antibacterial activity against Gram-positive and Gram-negative causing severe diseases and are widely used in human disease treatment, animal husbandry disease prevention, treatment and food additives. Abuse of sulfamethazine will accumulate residues in the environment and organisms for a long time, which will easily lead to high levels of drug resistance, and may cause carcinogenicity and teratogenicity in severe cases. Scholars at home and abroad have confirmed the existence of sulfonamide antibiotic residues in soil and water environments, which has aroused widespread concern in environmental ecology. For this reason, timely detection and effective separation of ...

Claims

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Application Information

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IPC IPC(8): C08F267/06C08F220/28C08F222/14C08F226/06C08J9/26B01J20/26B01J20/30
Inventor 戴江栋邹永立孟敏佳周志平赵春艳闫永胜
Owner JIANGSU UNIV
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