Method for establishing high altitude cerebral edema animal model
A high-altitude cerebral edema, animal model technology, applied in animal husbandry and other directions, can solve the problems of difficult quantification and automatic control, poor repeatability, and insignificant symptoms induced by cerebral edema, and achieve increased oxygen consumption, enhanced respiratory rate and oxygen consumption. amount of effect
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Embodiment 1
[0022] Select 20 clean-grade Vistar male rats, and the weight of each rat is controlled at 185g-200g. The rats were placed in a hypobaric and hypoxic environment to move freely for 2 days, and the conditions of the hypobaric and hypoxic environment were as follows: the temperature was 4-7 degrees Celsius, the oxygen concentration was 0.020 mol / L, and the air pressure was 45KPa. Under this environment, the rats were given a normal amount of food and drink.
[0023] Two days later, mice were trained to swim under the same hypobaric hypoxic conditions. Swimming training lasted 4 days, with 6 swimming training sessions per day. The process of each swimming training is as follows: the rats swim in the swimming pool for 20 minutes under low pressure and hypoxic conditions, and then the rats rest for 15 minutes; Continue to swim for 20 minutes and then rest for 15 minutes; repeat this, practice 6 times a day.
[0024] After the 6-day experiment, the rats were identified and monito...
Embodiment 2
[0026] Select 20 clean-grade Vistar male rats, and the weight of each rat is controlled at 200g-215g. Rats were placed in a hypobaric hypoxic environment to move freely for 2 days, and the conditions of the hypobaric hypoxic environment were: temperature 7-10 degrees Celsius, oxygen concentration 0.020mol / L-0.027mol / L, air pressure 50KPa. Under this environment, the rats were given a normal amount of food and drink.
[0027] Two days later, mice were trained to swim under the same hypobaric hypoxic conditions. Swimming training lasted 6 days, with 6 swimming training sessions per day. The process of each swimming training is as follows: the rats swim in the swimming pool for 30 minutes under low pressure and hypoxic conditions, and then the rats rest for 25 minutes; Continue to swim for 30 minutes and then rest for 25 minutes; repeat this, practice 6 times a day.
[0028] After the 8-day experiment, the rats were identified and monitored for the symptoms of brain edema by u...
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