Lycium ruthenicum mill freckle-removing and whitening anti-aging essence and preparation method of essence
A black fruit wolfberry, freckle-removing and whitening technology, which is applied in the direction of pharmaceutical formulas, cosmetic preparations, dressing preparations, etc., can solve the problems of decreased skin resistance, unfavorable skin care, thinning and peeling of the cuticle of the skin, and restore elasticity and Gloss, good skin care effect, anti-spot effect
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[0030] The preparation method of the seaweed extract is as follows: the seaweed after removing impurities is washed and minced with a dilute acid solution with a pH of 2 to 4, ground and homogenized in a dilute acid solution with a pH of 2 to 4, and then homogenized The pulped seaweed is aged and sterilized at a temperature of 121-135°C and a pressure of 1-5 MPa for 0.5-2 hours, and the degraded seaweed pulp is adjusted to pH 5.0-7.0 by adding alkali, and the pre-cultivated seaweed pulp is inoculated into the adjusted seaweed slurry The probiotic strains are conventionally fermented, and then algin oligosaccharides are added to the fermented slurry for preparation to protect and proliferate the probiotics, and a slurry with a concentration of 20g / mL is prepared, which is the seaweed extract.
[0031] The black fruit Lycium barbarum extract used in the present invention is the water extract of black fruit Lycium barbarum fruit powder, and its specific preparation method can be: ...
Embodiment 3
[0044] Embodiment 3 stability detection of the present invention:
[0045] 1. The pH value is 6.9.
[0046] 2. Heat resistance test, put a bottle of sample in a complete package into an incubator (40±1)°C for 24 hours, and there will be no oil-water separation after returning to room temperature.
[0047] 3. Cold resistance test, put a bottle of sample in a complete package in the refrigerator at -5~-10°C for 24 hours, and there will be no delamination, thickening and discoloration after returning to room temperature.
[0048] 4. For centrifugation test, place a bottle of sample in a complete package in a centrifuge at 2000 rpm, and centrifuge for 30 minutes without oil-water separation.
[0049] It can be seen that the essence prepared in Example 3 of the present invention has good stability.
[0050] Embodiment 9 clinical experiment of the present invention and result
Embodiment 1
[0051] The whitening effect test of the product that embodiment 1 and embodiment 3 make:
[0052] Select 40 healthy and normal volunteers, divide them into 2 groups, 20 people in each group, and irradiate the inner wrist area with UVA to make the area partially tanned;
[0053] With the product A, B that embodiment 1 and embodiment 3 make respectively, smear to 2 groups of trial persons respectively, twice a day, smear 30 days, only smear on the tanned side of skin each time.
[0054] Table 2
[0055]
[0056] Test results: after 30 days, the skin of the product of the present invention applied to the local tanning area of each group of trial persons is generally whiter than the original unapplied skin, while the skin of the unapplied skin of the present invention is whiter than the original unapplied skin in the tanned area. darker. And after application, the pigment spots of the testers have a tendency to fade, and the skin where the application is applied is...
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