Combination medicine, ointment and application of green and yellow medicines
A technology of ointment and medicine, applied in the field of external medicine, can solve the problems of great pain for patients, unfavorable work and study of patients, etc., and achieve good active effect
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Embodiment 1
[0015] The investigation of embodiment 1 preparation condition
[0016] Weigh 100 g each of Coptidis Rhizoma and Folium Folium, and place them in a 2000 mL round bottom flask. Add water 5 times the weight of the medicinal material and decoct twice, 1 hour each time; filter; combine the medicinal liquid, concentrate it to 1:2, add ethanol to make the alcohol content reach 75%, and carry out alcohol precipitation treatment. Refrigerate for 24 hours and then filter to recover ethanol. After the mellow taste is exhausted, the medicinal solution is concentrated to a thick extract, and stored in cold storage. spare.
[0017] As shown in Table 1, after mixing the matrix. Add the main medicinal extract, stir with an electromagnetic stirrer at 70-80°C until fully emulsified, and cool to room temperature.
[0018] Determining the level of factors: take extract, stearic acid, liquid paraffin, and triethanolamine as the investigation factors, select 3 levels for each factor, and selec...
Embodiment 2
[0028] The preparation of embodiment 2 test medicines
[0029] Weigh 50g of Daqingye and 250g of Coptis chinensis, and place them in a 4000mL round bottom flask. Add water 5 times the weight of the medicinal material and decoct twice, 1 hour each time; filter; combine the medicinal liquid, concentrate it to 1:2, add ethanol to make the alcohol content reach 75%, and carry out alcohol precipitation treatment. Refrigerate for 24 hours and then filter to recover ethanol. After the mellow taste is exhausted, the medicinal solution is concentrated to a thick extract, and stored in cold storage. spare.
[0030] By stearic acid: the weight ratio of (liquid paraffin+triethanolamine) is 2:1 ratio configuration base, wherein liquid paraffin: the weight ratio of triethanolamine is 6:1; Press extract: base weight ratio 1:3 will main The drug is added to the extract, stirred with an electromagnetic stirrer at 70-80°C until fully emulsified, and cooled to room temperature to obtain the p...
Embodiment 3
[0035] Example 3 Xanthate combined drug ointment to investigate the activity of hemorrhoids
[0036] For the analgesic experiment, a total of 80 female mice with a body weight of (20±2) g were taken. They were fasted for 12 hours before the experiment, and the aluminum cylinder was heated in a constant temperature water bath to keep the temperature within the range of (55±0.5)°C. The mice were placed at the bottom of the cylinder, and timed immediately. Kicking and licking of the hind feet were regarded as the pain response indicators of the mice, and the time was stopped as the pain threshold. The mice whose pain threshold was within 10 seconds to 20 seconds were pre-selected, and measured twice in a row, and the average value was taken as the pre-drug value. The qualified mice were randomly divided into 8 groups, i.e. the distilled water control group, the drug groups I, II, and III obtained in Example 2, the Coptis rhizome group, the Daqingye group, the commercially availab...
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