Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for preventing or treating irritable bowel syndrome

A technique for irritable bowel syndrome and its composition, which is applied in the field of medicine, can solve problems such as the prevention or treatment of irritable bowel syndrome that have not been reported, and achieve the effects of facilitating quality control, simple production process, and improving stability

Active Publication Date: 2014-02-19
SICHUAN JISHENGTANG PHARMLS
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] No pharmaceutical composition composed of menthol and peony extract or paeoniflorin has been reported for the prevention or treatment of irritable bowel syndrome

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for preventing or treating irritable bowel syndrome
  • Pharmaceutical composition for preventing or treating irritable bowel syndrome
  • Pharmaceutical composition for preventing or treating irritable bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 The pharmacodynamics comparative experiment of the pharmaceutical composition of the present invention and the pharmaceutical composition described in CN1660259A

[0019] 1. Experimental materials

[0020] KM mice, weighing 18-22 g, normal grade; animal license number: SCXK (Sichuan) 2004-15, provided by Sichuan Academy of Medical Sciences.

[0021] Peony extract (prepared according to Example 13).

[0022] Contrast prescription drug group: crude drug Radix Paeoniae Alba: Peppermint oil is 130:1, (wherein Radix Paeoniae Alba extraction process prepares Radix Paeoniae Alba extract according to Example 13); Peppermint oil is: batch number 060113 (menthol purity: 47.2%, Xuchang, Henan Huaren Pharmaceutical Co., Ltd.). The above-mentioned raw materials (the Radix Paeoniae Alba extract prepared from 130 parts of Radix Paeoniae Alba and 1 part of peppermint oil) are uniformly mixed to obtain the product.

[0023] Pharmaceutical composition containing peony ext...

Embodiment 2

[0032] Embodiment two The pharmaceutical composition of the present invention is compared with the pharmacodynamics experiment of the pharmaceutical composition described in CN1660259A

[0033] 1. Experimental materials

[0034] KM mice, weighing 18-22 g, normal grade; animal license number: SCXK (Sichuan) 2004-15, provided by Sichuan Academy of Medical Sciences.

[0035] Paeoniflorin: batch number 061026, purity 90.5% (refer to the content determination method under "Paeoniae Alba" in the 2005 edition of "Chinese Pharmacopoeia"). Preparation method: after peony is crushed, decoct with 8 times the amount of water for 3 times, each time for 1 hour, the extract is absorbed by D101 macroporous resin, eluted with 50% ethanol, recovered ethanol, concentrated and dried to obtain the extract. The pure paeoniflorin was separated by normal pressure column chromatography.

[0036] Menthol: batch number 060513, purity 99.8%. Produced by Guangzhou Pharmaceutical Chemicals.

[0037] Co...

Embodiment 3

[0046] Example 3 Acute Toxicity Comparison of the Pharmaceutical Composition of the Present Invention and the Comparative Prescription (CN1660259A)

[0047] 1. Experimental materials

[0048] Paeoniae officinalis extract: Same as "Peoniae officinalis extract" in Example 1.

[0049] Menthol: Menthol: batch number 060513, purity 99.8%, produced by Guangzhou Pharmaceutical Chemicals.

[0050] Paeoniflorin: the same as "Paeoniflorin" in Example 2.

[0051] Comparative prescription drug group: prepared according to the comparative prescription drug group in Example 1.

[0052] 2. Experimental method

[0053] Pharmaceutical composition group LD with the ratio of Paeoniae officinalis extract and menthol at a ratio of 2:1 50 Value determination: According to the preliminary test results, the total lethal dose (Dm) of the drug group is 10g / kg, and the zero lethal dose (Dn) is 4g / kg. Take 50 mice and divide them into 5 groups at random, 10 in each group, half male and half male. St...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pharmaceutical composition for preventing or treating an irritable bowel syndrome. A menthol or paeoniflorin extract, or menthol and paeoniflorin is used as active components, and the medicine in different preparation types can be prepared by adding pharmaceutical acceptable auxiliary materials. The pharmaceutical composition has the definite effective components, small dosage and good safety. Pharmacodynamic tests prove that the pharmaceutical composition has a spasmolysis function, an anti-inflammatory function and an analgetic function definitely, and the pharmaceutical composition has good curative effects for the diarrhetic irritable bowel syndrome.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for preventing or treating irritable bowel syndrome. Background technique [0002] Irritable bowel syndrome (IBS) is a group of clinical syndromes including abdominal pain, bloating, changes in bowel habits, abnormal stool shape, and mucus stools, which persist or recur. According to clinical manifestations, IBS can be roughly divided into four types: diarrhea type, constipation type, alternating diarrhea and constipation type, and abdominal pain type, of which the diarrhea type accounts for about 2 / 3. Epidemiological surveys show that 10%-20% of adults and adolescents in the world have IBS symptoms, women are more than men, and the sex ratio between men and women is between 1:1 and 1:2 [Ning Liqin, Ye Bai, Irritable Bowel Syndrome Advances in Research on Syndrome, Modern Medicine, 2008,36(6):499-452]. [0003] A large number of studies have show...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/71A61K31/7048A61P1/00A61K31/045
Inventor 柯潇高小平吴建明
Owner SICHUAN JISHENGTANG PHARMLS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com