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Coating premix matched with stomach/intestine-dissolved polyacrylic resin latex and preparation method thereof

A technology of polyacrylic acid resin and coating premix is ​​applied in the fields of medicinal stomach and enteric coating materials, which can solve the problems of high cost, flammability, explosion and the like, and achieves low production cost, short coating time, Stable quality effect

Inactive Publication Date: 2014-02-26
悦康药业集团安徽天然制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyacrylic acid resins are polyacrylic acid resins polymerized by polymer materials. The coating material needs to be dissolved with a large amount of alcohol during use. The disadvantages are: high cost, flammable, explosive, and three wastes
[0003] However, there is no matching coating powder for polyacrylic acid resin emulsion (enteric-coated type) and polyacrylic acid resin emulsion (gastric collapse type). Although the coating material is good, it is very inconvenient for pharmaceutical companies to use, and they prepare batches by themselves. too much difference

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A stomach and enteric-coating type-coating premix for polyacrylic acid resin emulsion, which is made of the following raw materials in the weight ratio: hypromellose: 350, polyethylene glycol 6000: 55, talc Powder: 250, Polysorbate-80: 150, Titanium Dioxide: 25, Lakes of various colors: 2. It can be prepared by conventional polymerization process.

Embodiment 2

[0023] A stomach and enteric-coating type-coating premix for polyacrylic acid resin emulsion, which is made of the following raw materials in the weight ratio: hypromellose: 400, polyethylene glycol 6000: 60, talc Powder: 300, Polysorbate-80: 130, Titanium Dioxide: 35, Lakes of various colors: 5.

[0024] Its preparation method steps are as follows:

[0025] Weigh hypromellose, polyethylene glycol-6000, talcum powder, titanium dioxide and color lake (firstly grind for 0.5-1 hour) which have been passed through a 100-mesh sieve, and add them to the tank-type motion mixer in turn. After mixing for 1 hour, Add polysorbate-80 while stirring to make it evenly mixed; take out the mixed materials in the above-mentioned tank mixer and add them to the swing granulator, granulate, repeat three times, transfer to the three-dimensional mixer for final mixing, and pack after completion . That is the finished product.

Embodiment 3

[0027] A stomach and enteric-coating type-coating premix for polyacrylic acid resin emulsion, which is made of the following raw materials in the weight ratio: hypromellose: 400, polyethylene glycol 6000: 60, talc Powder: 300, Polysorbate-80: 150, Titanium Dioxide: 30, Lakes of various colors: 10.

[0028] Get the polyacrylic acid resin latex solution prepared by the present embodiment and test it with coating premix gastric and enteric-coated "Chinese Pharmacopoeia", and the results are as follows:

[0029] 1. Traits

[0030] This product is an amorphous powder with uniform color; odorless and tasteless.

[0031] [0015] 2. Identification:

[0032] A. Take 1.0g of this product, add 10ml of water to mix, grind evenly, then add 10ml of polyacrylic resin latex, stir slowly, take an appropriate amount and pour it on a glass plate, dry at 40°C for 1-2 hours, take it out and let it cool, it should form A uniform film. For the film compatible with polyacrylic acid resin latex (...

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Abstract

The invention discloses a coating premix matched with stomach / intestine-dissolved polyacrylic resin latex. The coating premix is prepared from the following raw materials in parts by weight: 350-400 parts of hydroxypropyl methylcellulose, 55-60 parts of polyethylene glycol 6000, 250-300 parts of talcum powder, 150-200 parts of polysorbate-80, 0-50 parts of titania and 50-0 part of various colored lakes. The invention further discloses a method for preparing the coating premix matched with the polyacrylic resin latex. The coating premix matched with the polyacrylic resin latex, prepared by the method, belongs to physical mixtures. The prepared coating premix matched with the polyacrylic resin latex is matched with polyacrylic resin latex (stomach-collapsed type) and polyacrylic resin latex (intestine-dissolved type), can coat stomach-dissolved preparations and intestine-dissolved preparations and has the advantages of good plasticity, easiness in film forming, and the like.

Description

Technical field [0001] The present invention mainly involves the field of medicinal gastric and entero -soluble wrap materials, especially the gastric and enteric polyacrylic resin latex liquids involved in a coated premier and its method for the gastric and enteric polyacrylic resin. Background technique [0002] At present, domestic drugs and enteric coats used in China include polyacrylate resin No. Ⅱ or III, polyacrylic resin No. IV, and hydroxydonia and coated powder.Polyacrylate resin is a polyacrylate resin using polymer material polymerization. The coated material needs to be dissolved with a lot of alcohol in use. The disadvantage is: high cost, flammable, explosive, and three wastes. [0003] The polyacrylic resin latex (enteric -soluble) and polyacrylic resin latex (gastric collapse) without matching coat powder powder. Although the coating material is good, it is very inconvenient to use pharmaceutical companies.The difference is too big.Therefore, developing a coat p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/38A61K47/32A61K47/34A61K47/26A61K47/04
Inventor 李玉生李金林
Owner 悦康药业集团安徽天然制药有限公司
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