Application of Gossypol Acetate in Pharmaceuticals

Abstract

The invention discloses a novel application of gossypol acetate in the field of pharmacy, and in particular relates to an application of gossypol acetate in preparing medicines for preventing, relieving and / or treating reye's syndrome, and belongs to the field of pharmacy. Reye's syndrome is a cryptogenic acute encephalopathy syndrome in the childhood phase, and studies discover that loss or mutation of MeCP2 gene has a direct causal relationship with the reye's syndrome, and loss of the MeCP2 gene can cause reye's syndrome developing on a mouse. Experiments indicate that the content of the MeCP2 gene in the brain of a rat can be remarkably increased by administrating the rat with gossypol acetate, so that the content of the MeCP2 gene in the brain of a patient can be remarkably increased by using the gossypol acetate for preventing, relieving and treating the reye's syndrome caused by MeCP2 mutation, the development of the nerve cell of the patient can be promoted, functions of the nervous system can be restored, and the possibility of healing the patient can be increased. Therefore, according to the application of the gossypol acetate in preparing the medicine for resisting reye's syndrome, the medicine can be used for preventing, relieving and / or treating the reye's syndrome.

Description

technical field [0001] The invention relates to the application of gossypol acetate in the pharmaceutical field, in particular to the application of gossypol acetate in the preparation of anti-Reye's syndrome medicine. Background technique [0002] Reye's syndrome is a severe X-chromosome-linked neurodevelopmental autism spectrum disorder (autism spectrum disorder), and it is a recognized MeCP2 (methylCpG–bindingprotein2, methylated CpG binding protein 2) monogenic disease at home and abroad. Studies have found that there is a direct causal relationship between the loss or mutation of the MeCP2 gene and Reye's syndrome, which provides a potential therapeutic target for Reye's syndrome. Studies on the mouse model of Reye's syndrome found that the restoration of MeCP2 function can reverse the neurological symptoms of adult mice, making it possible for patients with Reye's syndrome to be cured. [0003] Gossypol acetate is a polyphenolic compound with extensive pharmacological...

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Problems solved by technology

[0007] In the prior art, the research on the use of gossypol acetate mainly focuses on the treatment of gynecological diseases such as tumors of the reproductive system of men and women, endometriosis, etc., and its application in the preparation of Reye's syndrome drugs for the treatment of MeCP2 mutations has not been found yet.

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